NP_079470.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
75,207 Da
NCBI Official Full Name
inositol-trisphosphate 3-kinase C
NCBI Official Synonym Full Names
inositol-trisphosphate 3-kinase C
NCBI Protein Information
inositol-trisphosphate 3-kinase C; IP3K C; IP3 3-kinase C; InsP 3 kinase C; insP 3-kinase C; inositol 1,4,5-trisphosphate 3-kinase C
UniProt Protein Name
Inositol-trisphosphate 3-kinase C
UniProt Synonym Protein Names
Inositol 1,4,5-trisphosphate 3-kinase C; IP3 3-kinase C; IP3K C; InsP 3-kinase C
UniProt Synonym Gene Names
UniProt Entry Name
IP3KC_HUMAN
NCBI Summary for ITPKC
This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
UniProt Comments for ITPKC
ITPKC: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. Defects in ITPKC are a cause of Kawasaki disease (KWD); also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self- limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries. Belongs to the inositol phosphokinase (IPK) family.
Protein type: EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.1
Cellular Component: nucleus; cytosol
Molecular Function: calmodulin binding; inositol trisphosphate 3-kinase activity; ATP binding
Biological Process: inositol phosphate metabolic process; phosphorylation
Disease: Kawasaki Disease
Research Articles on ITPKC
Precautions
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Pathways associated with ITPKC elisa kit
Products by Pathway |
Pathway Diagram |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram |
Superpathway Of D-myo-inositol (1,4,5)-trisphosphate Metabolism antibodies |
Superpathway Of D-myo-inositol (1,4,5)-trisphosphate Metabolism Diagram |
Superpathway Of D-myo-inositol (1,4,5)-trisphosphate Metabolism antibodies |
Superpathway Of D-myo-inositol (1,4,5)-trisphosphate Metabolism Diagram |
Superpathway Of Inositol Phosphate Compounds antibodies |
Superpathway Of Inositol Phosphate Compounds Diagram |
Diseases associated with ITPKC elisa kit
Organs/Tissues associated with ITPKC elisa kit
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