NP_055030.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
143,720 Da
NCBI Official Full Name
insulin receptor-related protein
NCBI Official Synonym Full Names
insulin receptor-related receptor
NCBI Official Synonym Symbols
NCBI Protein Information
insulin receptor-related protein; IR-related receptor
UniProt Protein Name
Insulin receptor-related protein
UniProt Synonym Protein Names
IR-related receptorCleaved into the following 2 chains:Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain
UniProt Synonym Gene Names
UniProt Entry Name
INSRR_HUMAN
UniProt Comments for INSRR
IRR: Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Protein type: Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; InsR family
Chromosomal Location of Human Ortholog: 1q21-q23
Cellular Component: integral to plasma membrane; receptor complex
Molecular Function: insulin receptor substrate binding; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; male sex determination; actin cytoskeleton reorganization; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on INSRR
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Products associated with INSRR elisa kit
Pathways associated with INSRR elisa kit
Diseases associated with INSRR elisa kit
Organs/Tissues associated with INSRR elisa kit
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