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ITGA3 elisa kit :: Human integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS943456
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
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 Product Name   

integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3), ELISA Kit

★Popular Item★
 Also Known As   

Human Integrin alpha-3, ITGA3 ELISA Kit

 Product Synonym Names    Human Integrin alpha-3 (ITGA3) ELISA kit; CD49C; FLJ34631; FLJ34704; GAP-B3; GAPB3; MSK18; VCA-2; VL3A; VLA3a; antigen identified by monoclonal antibody J143; galactoprotein B3; integrin alpha 3; very late activation protein 3 receptor; alpha-; integrin; alpha 3 (antigen CD49C; alpha 3 subunit of VLA-3 receptor)
 Product Gene Name   

ITGA3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS943456 Testing Data    Testing Data PDF
 OMIM    gene 614748
 3D Structure    ModBase 3D Structure for P26006
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human ITGA3. No significant cross-reactivity or interference between human ITGA3 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, cell lysates.
 Assay Type    Sandwich
 Detection Range    93.75 pg/ml -6000 pg/ml.
 Sensitivity    The minimum detectable dose of human ITGA3 is typically less than 23.4 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of ITGA3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for ITGA3 purchase    MBS943456 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) (ITGA3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 93.75 pg/ml -6000 pg/ml. in biological research samples containing ITGA3, with an estimated sensitivity of The minimum detectable dose of human ITGA3 is typically less than 23.4 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS943456 kit is based on ITGA3 antibody-ITGA3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ITGA3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ITGA3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for ITGA3 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ITGA3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ITGA3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ITGA3 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ITGA3 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of ITGA3 elisa kit    ITGA3 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS943456. Click to request current manual
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NCBI/Uniprot data below describe general gene information for ITGA3. It may not necessarily be applicable to this product.
 NCBI GI #    4504747
 NCBI GeneID    3675
 NCBI Accession #    NP_002195.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002204.2 [Other Products]
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 UniProt Primary Accession #    P26006 [Other Products]
 UniProt Secondary Accession #    A7E246; B7ZM80; B9EGQ1; D3DTX4; D3DTX5 [Other Products]
 UniProt Related Accession #    P26006 [Other Products]
 Molecular Weight    116,612 Da
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 NCBI Official Full Name    integrin alpha-3 isoform a
 NCBI Official Synonym Full Names    integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 NCBI Official Symbol    ITGA3 [Similar Products]
 NCBI Official Synonym Symbols   
VL3A; CD49C; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
[Similar Products]
 NCBI Protein Information    integrin alpha-3; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal antibody J143; very late activation protein 3 receptor, alpha-3 subunit
 UniProt Protein Name    Integrin alpha-3
 UniProt Synonym Protein Names   
CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD_antigen: CD49cCleaved into the following 2 chains:Integrin alpha-3 heavy chain; Integrin alpha-3 light chain
 Protein Family    Integrin
 UniProt Gene Name    ITGA3 [Similar Products]
 UniProt Synonym Gene Names    MSK18; GAPB3 [Similar Products]
 UniProt Entry Name    ITA3_HUMAN
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 NCBI Summary for ITGA3    The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ITGA3    ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described.

Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: filopodium membrane; growth cone; cell surface; focal adhesion; perinuclear region of cytoplasm; basolateral plasma membrane; plasma membrane; excitatory synapse; integrin complex; receptor complex; external side of plasma membrane

Molecular Function: collagen binding; integrin binding; protein domain specific binding; protein binding; protease binding; protein heterodimerization activity; fibronectin binding; metal ion binding; laminin binding; glycoprotein binding

Biological Process: integrin-mediated signaling pathway; skin development; response to drug; extracellular matrix organization and biogenesis; maternal process involved in pregnancy; cell-matrix adhesion; heart development; regulation of BMP signaling pathway; neuron migration; regulation of Wnt receptor signaling pathway; mesodermal cell differentiation; memory; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of Rho protein signal transduction; blood coagulation; leukocyte migration; negative regulation of cell projection organization and biogenesis; lung development

Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
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 Research Articles on ITGA3    1. ITGA3 gene polymorphism is associated with with susceptibility of osteosarcoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ITGA3 elisa kitPathways associated with ITGA3 elisa kit
 Reference Product  PubMed Publications
 ITGB1 elisa kit  >3 publications with ITGA3 and ITGB1
 FN1 elisa kit  >2 publications with ITGA3 and FN1
 TSPAN4 elisa kit  >1 publications with ITGA3 and TSPAN4
 CD9 elisa kit  >1 publications with ITGA3 and CD9
 CD82 elisa kit  >1 publications with ITGA3 and CD82
 CD151 elisa kit  >1 publications with ITGA3 and CD151
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
Diseases associated with ITGA3 elisa kitOrgans/Tissues associated with ITGA3 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with ITGA3 and Neoplasms
 Neoplasm Metastasis Antibodies  >6 publications with ITGA3 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >4 publications with ITGA3 and Carcinoma, Squamous Cell
 Neoplasm Invasiveness Antibodies  >3 publications with ITGA3 and Neoplasm Invasiveness
 Nervous System Diseases Antibodies  >2 publications with ITGA3 and Nervous System Diseases
 Adenocarcinoma Antibodies  >2 publications with ITGA3 and Adenocarcinoma
 Lung Neoplasms Antibodies  >2 publications with ITGA3 and Lung Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with ITGA3 and Congenital Abnormalities
 Skin Diseases Antibodies  >1 publications with ITGA3 and Skin Diseases
 Hematologic Diseases Antibodies  >1 publications with ITGA3 and Hematologic Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >3 publications with ITGA3 and Nerve
 Lymph Node Antibodies  >3 publications with ITGA3 and Lymph Node
 Stomach Antibodies  >2 publications with ITGA3 and Stomach
 Skin Antibodies  >2 publications with ITGA3 and Skin
 Embryonic Tissue Antibodies  >2 publications with ITGA3 and Embryonic Tissue
 Lung Antibodies  >2 publications with ITGA3 and Lung
 Brain Antibodies  >2 publications with ITGA3 and Brain
 Blood Antibodies  >2 publications with ITGA3 and Blood
 Mouth Antibodies  >1 publications with ITGA3 and Mouth
 Esophagus Antibodies  >1 publications with ITGA3 and Esophagus
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