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IFNAR2 elisa kit :: Human interferon (alpha, beta and omega) receptor 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS906140
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

interferon (alpha, beta and omega) receptor 2 (IFNAR2), ELISA Kit

 Also Known As   

Human Interferon alpha/beta receptor 2, IFNAR2 ELISA Kit

 Product Synonym Names    Human Interferon alpha/beta receptor 2 (IFNAR2) ELISA kit; IFN-R; IFN-alpha-REC; IFNABR; IFNARB; OTTHUMP00000067674; human interferon alpha/beta receptor; interferon alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; type I interferon receptor; interferon (alpha; beta and omega) receptor 2
 Product Gene Name   

IFNAR2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS906140 Testing Data    Testing Data PDF
 OMIM    gene 610424
 3D Structure    ModBase 3D Structure for P48551
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human IFNAR2. No significant cross-reactivity or interference between Human IFNAR2 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, cell culture supernates
 Assay Type    Sandwich
 Detection Range    0.156 ng/ml-10 ng/ml
 Sensitivity    0.039 ng/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of IFNAR2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for IFNAR2 purchase    MBS906140 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the interferon (alpha, beta and omega) receptor 2 (IFNAR2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156 ng/ml-10 ng/ml in biological research samples containing IFNAR2, with an estimated sensitivity of 0.039 ng/ml. The ELISA analytical biochemical technique of the MBS906140 kit is based on IFNAR2 antibody-IFNAR2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFNAR2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFNAR2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, cell culture supernates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for IFNAR2 elisa kit

   For SamplesFor the quantitative determination of human interferon alpha/beta receptor 2 (IFNAR2) concentrations in serum, plasma, cell culture supernates, tissue homogenates.

PRINCIPLE OF THE ASSAY This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for IFNAR2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any IFNAR2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for IFNAR2 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of IFNAR2 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of IFNAR2 elisa kit    IFNAR2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS906140. Click to request current manual
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NCBI/Uniprot data below describe general gene information for IFNAR2. It may not necessarily be applicable to this product.
 NCBI GI #    19923129
 NCBI GeneID    3455
 NCBI Accession #    NP_000865.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000874.4 [Other Products]
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 UniProt Primary Accession #    P48551 [Other Products]
 UniProt Secondary Accession #    Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9 [Other Products]
 UniProt Related Accession #    P48551 [Other Products]
 Molecular Weight    57,759 Da
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 NCBI Official Full Name    interferon alpha/beta receptor 2 isoform b
 NCBI Official Synonym Full Names    interferon (alpha, beta and omega) receptor 2
 NCBI Official Symbol    IFNAR2 [Similar Products]
 NCBI Official Synonym Symbols   
IFN-R; IFNABR; IFNARB; IFN-alpha-REC
[Similar Products]
 NCBI Protein Information    interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain
 UniProt Protein Name    Interferon alpha/beta receptor 2
 UniProt Synonym Protein Names   
Interferon alpha binding protein; Type I interferon receptor 2
 Protein Family    Interferon alpha/beta receptor
 UniProt Gene Name    IFNAR2 [Similar Products]
 UniProt Synonym Gene Names    IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2 [Similar Products]
 UniProt Entry Name    INAR2_HUMAN
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 NCBI Summary for IFNAR2    The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNAR2    IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular space; integral to plasma membrane; extracellular region; plasma membrane

Molecular Function: protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade

Disease: Hepatitis B Virus, Susceptibility To
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 Research Articles on IFNAR2    1. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with IFNAR2 elisa kitPathways associated with IFNAR2 elisa kit
 Reference Product  PubMed Publications
 IFNA2 elisa kit  >165 publications with IFNAR2 and IFNA2
 IFNAR1 elisa kit  >123 publications with IFNAR2 and IFNAR1
 STAT1 elisa kit  >26 publications with IFNAR2 and STAT1
 STAT2 elisa kit  >22 publications with IFNAR2 and STAT2
 JAK1 elisa kit  >21 publications with IFNAR2 and JAK1
 TYK2 elisa kit  >19 publications with IFNAR2 and TYK2
 STAT3 elisa kit  >11 publications with IFNAR2 and STAT3
 USP18 elisa kit  >4 publications with IFNAR2 and USP18
 IFNB1 elisa kit  >1 publications with IFNAR2 and IFNB1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with IFNAR2 elisa kitOrgans/Tissues associated with IFNAR2 elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >22 publications with IFNAR2 and Liver Diseases
 Carcinoma Antibodies  >18 publications with IFNAR2 and Carcinoma
 Adenocarcinoma Antibodies  >14 publications with IFNAR2 and Adenocarcinoma
 Nervous System Diseases Antibodies  >13 publications with IFNAR2 and Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with IFNAR2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >7 publications with IFNAR2 and Liver Neoplasms
 Necrosis Antibodies  >7 publications with IFNAR2 and Necrosis
 Cardiovascular Diseases Antibodies  >6 publications with IFNAR2 and Cardiovascular Diseases
 Inflammation Antibodies  >6 publications with IFNAR2 and Inflammation
 Kidney Diseases Antibodies  >5 publications with IFNAR2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >41 publications with IFNAR2 and Blood
 Liver Antibodies  >23 publications with IFNAR2 and Liver
 Lung Antibodies  >8 publications with IFNAR2 and Lung
 Bone Marrow Antibodies  >6 publications with IFNAR2 and Bone Marrow
 Kidney Antibodies  >6 publications with IFNAR2 and Kidney
 Uterus Antibodies  >5 publications with IFNAR2 and Uterus
 Brain Antibodies  >4 publications with IFNAR2 and Brain
 Spleen Antibodies  >3 publications with IFNAR2 and Spleen
 Skin Antibodies  >1 publications with IFNAR2 and Skin
 Lymph Node Antibodies  >1 publications with IFNAR2 and Lymph Node
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