NP_001190192.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
86,240 Da
NCBI Official Full Name
interleukin-17 receptor C isoform 4
NCBI Official Synonym Full Names
interleukin 17 receptor C
NCBI Protein Information
interleukin-17 receptor C; IL-17RL; IL17Rhom; zcytoR14; IL17F receptor; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein
UniProt Protein Name
Interleukin-17 receptor C
UniProt Synonym Protein Names
Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14
UniProt Synonym Gene Names
UNQ6118/PRO20040/PRO38901; IL-17 receptor C; IL-17RC; IL17Rhom; IL-17RL [Similar Products]
UniProt Entry Name
I17RC_HUMAN
NCBI Summary for IL17RC
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
UniProt Comments for IL17RC
IL17RC: a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p25.3|3p25.3-p24.1
Cellular Component: integral to plasma membrane
Molecular Function: interleukin-17 receptor activity
Biological Process: cytokine and chemokine mediated signaling pathway
Disease: Candidiasis, Familial, 9
Research Articles on IL17RC
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Diseases associated with IL17RC elisa kit
Organs/Tissues associated with IL17RC elisa kit
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