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KLK4 elisa kit :: Human kallikrein-related peptidase 4 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS917102 KLK4 elisa kit
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

kallikrein-related peptidase 4 (KLK4), ELISA Kit

★Popular Item★
 Also Known As   

Human Kallikrein-4, KLK4 ELISA Kit

 Product Synonym Names    Human Kallikrein-4 (KLK4) ELISA kit; AI2A1; ARM1; EMSP; EMSP1; KLK-L1; MGC116827; MGC116828; PROSTASE; PRSS17; PSTS; androgen-regulated message 1; enamel matrix serine protease 1; kallikrein 4 (prostase; enamel matrix; prostate) ; kallikre; kallikrein-related peptidase 4
 Product Gene Name   

KLK4 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603767
 3D Structure    ModBase 3D Structure for Q9Y5K2
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human KLK4. No significant cross-reactivity or interference between human KLK4 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates.
 Assay Type    Sandwich
 Detection Range    0.156 ng/ml -10 ng/ml.
 Sensitivity    The minimum detectable dose of human KLK4 is typically less than 0.039 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KLK4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KLK4 purchase    MBS917102 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the kallikrein-related peptidase 4 (KLK4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.156 ng/ml -10 ng/ml in biological research samples containing KLK4, with an estimated sensitivity of The minimum detectable dose of human KLK4 is typically less than 0.039 ng/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS917102 kit is based on KLK4 antibody-KLK4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KLK4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KLK4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for KLK4 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for KLK4 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any KLK4 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for KLK4 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of KLK4 bound in the initial step. The color development is stopped and the intensity of the color is measured.
Sample Manual Insert of MBS917102. Click to request current manual
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NCBI/Uniprot data below describe general gene information for KLK4. It may not necessarily be applicable to this product.
 NCBI GI #    89142741
 NCBI GeneID    9622
 NCBI Accession #    NP_004908.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_004917.3 [Other Products]
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 UniProt Primary Accession #    Q9Y5K2 [Other Products]
 UniProt Secondary Accession #    Q4VB16; Q9GZL6; Q9UBJ6 [Other Products]
 UniProt Related Accession #    Q9Y5K2 [Other Products]
 Molecular Weight    27,032 Da
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 NCBI Official Full Name    kallikrein-4 preproprotein
 NCBI Official Synonym Full Names    kallikrein-related peptidase 4
 NCBI Official Symbol    KLK4 [Similar Products]
 NCBI Official Synonym Symbols   
ARM1; EMSP; PSTS; AI2A1; EMSP1; KLK-L1; PRSS17; kallikrein
[Similar Products]
 NCBI Protein Information    kallikrein-4; prostase; serine protease 17; kallikrein-like protein 1; androgen-regulated message 1; enamel matrix serine protease 1; enamel matrix serine proteinase 1
 UniProt Protein Name    Kallikrein-4
 UniProt Synonym Protein Names   
Enamel matrix serine proteinase 1; Kallikrein-like protein 1; KLK-L1; Prostase; Serine protease 17
 Protein Family    Kallikrein
 UniProt Gene Name    KLK4 [Similar Products]
 UniProt Synonym Gene Names    EMSP1; PRSS17; PSTS; KLK-L1 [Similar Products]
 UniProt Entry Name    KLK4_HUMAN
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 NCBI Summary for KLK4    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KLK4    KLK4: Involved in enamel formation. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1). AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. Belongs to the peptidase S1 family. Kallikrein subfamily.

Protein type: Protease; Secreted, signal peptide; EC 3.4.21.-; Secreted

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function: serine-type peptidase activity; metal ion binding; serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; protein catabolic process; proteolysis

Disease: Amelogenesis Imperfecta, Hypomaturation Type, Iia1
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 Research Articles on KLK4    1. These results demonstrate that the activities of AR and mTOR pathways are maintained by KLK4, which may thus be a viable target for therapy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KLK4 elisa kitDiseases associated with KLK4 elisa kit
 Reference Product  PubMed Publications
 SHBG elisa kit  >1 publications with KLK4 and SHBG
 Disease Name  Pubmed Publications
 Neoplasms, Glandular and Epithelial Antibodies  >8 publications with KLK4 and Neoplasms, Glandular and Epithelial
 Inflammation Antibodies  >3 publications with KLK4 and Inflammation
 Hyperplasia Antibodies  >3 publications with KLK4 and Hyperplasia
 Liver Neoplasms Antibodies  >1 publications with KLK4 and Liver Neoplasms
 Colonic Neoplasms Antibodies  >1 publications with KLK4 and Colonic Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with KLK4 and Neoplasm Metastasis
 Postoperative Complications Antibodies  >1 publications with KLK4 and Postoperative Complications
 Muscle Weakness Antibodies  >1 publications with KLK4 and Muscle Weakness
 Lung Diseases Antibodies  >1 publications with KLK4 and Lung Diseases
 Bronchial Neoplasms Antibodies  >1 publications with KLK4 and Bronchial Neoplasms
Organs/Tissues associated with KLK4 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >41 publications with KLK4 and Prostate
 Blood Antibodies  >11 publications with KLK4 and Blood
 Brain Antibodies  >2 publications with KLK4 and Brain
 Uterus Antibodies  >2 publications with KLK4 and Uterus
 Uncharacterized Tissue Antibodies  >1 publications with KLK4 and Uncharacterized Tissue
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