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KPNB1 elisa kit :: Human karyopherin (importin) beta 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9319158 KPNB1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

karyopherin (importin) beta 1 (KPNB1), ELISA Kit

 Also Known As   

Human Importin subunit beta-1, KPNB1 ELISA Kit

 Product Synonym Names    Human Importin subunit beta-1 (KPNB1) ELISA kit; IMB1; IPO1; IPOB; Impnb; MGC2155; MGC2156; MGC2157; NTF97; importin 1; importin 90; importin beta-1 subunit; karyopherin beta 1; nuclear factor p97; karyopherin (importin) beta 1
 Product Gene Name   

KPNB1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    602738
 3D Structure    ModBase 3D Structure for Q14974
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of KPNB1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KPNB1 purchase    MBS9319158 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the karyopherin (importin) beta 1 (KPNB1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KPNB1. The ELISA analytical biochemical technique of the MBS9319158 kit is based on KPNB1 antibody-KPNB1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KPNB1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KPNB1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for KPNB1. It may not necessarily be applicable to this product.
 NCBI GI #    449784879
 NCBI GeneID    3837
 NCBI Accession #    NP_001263382.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001276453.1 [Other Products]
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 UniProt Primary Accession #    Q14974 [Other Products]
 UniProt Secondary Accession #    Q14637; Q53XN2; Q96J27; B7ZAV6; D3DTT3 [Other Products]
 UniProt Related Accession #    Q14974 [Other Products]
 Molecular Weight    97,170 Da
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 NCBI Official Full Name    importin subunit beta-1 isoform 2
 NCBI Official Synonym Full Names    karyopherin (importin) beta 1
 NCBI Official Symbol    KPNB1 [Similar Products]
 NCBI Official Synonym Symbols   
IMB1; IPO1; IPOB; Impnb; NTF97
[Similar Products]
 NCBI Protein Information    importin subunit beta-1; PTAC97; importin 1; importin 90; importin-90; nuclear factor p97; importin beta-1 subunit; karyopherin subunit beta-1; pore targeting complex 97 kDa subunit
 UniProt Protein Name    Importin subunit beta-1
 UniProt Synonym Protein Names   
Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; Pore targeting complex 97 kDa subunit; PTAC97
 Protein Family    Importin
 UniProt Gene Name    KPNB1 [Similar Products]
 UniProt Synonym Gene Names    NTF97; PTAC97 [Similar Products]
 UniProt Entry Name    IMB1_HUMAN
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 NCBI Summary for KPNB1    Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
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 UniProt Comments for KPNB1    KPNB1: a nuclear import protein nuclear protein import that functions either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus. Forms a complex with an importin alpha subunit. Forms a heterodimer with IPO7. Interacts with IPO7, SNUPN, RPL23A and XPO1. Two isoforms of the human protein have been reported. Belongs to the importin beta family.

Protein type: Nuclear import; Karyopherin

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: nucleoplasm; nuclear membrane; membrane; cytoplasm; nuclear envelope; nuclear pore; cytosol

Molecular Function: protein domain specific binding; protein binding; enzyme binding; zinc ion binding; nuclear localization sequence binding; Ran GTPase binding; protein transporter activity

Biological Process: ribosomal protein import into nucleus; viral reproduction; apoptosis; protein import into nucleus; protein import into nucleus, translocation; cytokine and chemokine mediated signaling pathway; viral infectious cycle; NLS-bearing substrate import into nucleus; DNA fragmentation during apoptosis; cell structure disassembly during apoptosis
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 Research Articles on KPNB1    1. Knockdown of KPNB1 reduced the amount of nuclear p65 following TNF stimulation. KPNB1 binding to p65 is NLS dependent.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with KPNB1 elisa kitPathways associated with KPNB1 elisa kit
 Reference Product  PubMed Publications
 RAN elisa kit  >12 publications with KPNB1 and RAN
 KPNA2 elisa kit  >5 publications with KPNB1 and KPNA2
 RANBP2 elisa kit  >1 publications with KPNB1 and RANBP2
 PTHLH elisa kit  >1 publications with KPNB1 and PTHLH
 NUP50 elisa kit  >1 publications with KPNB1 and NUP50
 NUP153 elisa kit  >1 publications with KPNB1 and NUP153
 FGFR1 elisa kit  >1 publications with KPNB1 and FGFR1
 Products by Pathway  Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 Host Interactions Of HIV Factors Pathway antibodies  Host Interactions Of HIV Factors Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
Diseases associated with KPNB1 elisa kitOrgans/Tissues associated with KPNB1 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with KPNB1 and Neoplasms
 Brain Diseases Antibodies  >3 publications with KPNB1 and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with KPNB1 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with KPNB1 and Cardiovascular Diseases
 Inflammation Antibodies  >2 publications with KPNB1 and Inflammation
 Disease Models, Animal Antibodies  >1 publications with KPNB1 and Disease Models, Animal
 Heart Failure Antibodies  >1 publications with KPNB1 and Heart Failure
 Fetal Death Antibodies  >1 publications with KPNB1 and Fetal Death
 Urogenital Abnormalities Antibodies  >1 publications with KPNB1 and Urogenital Abnormalities
 Breast Neoplasms Antibodies  >1 publications with KPNB1 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with KPNB1 and Brain
 Heart Antibodies  >2 publications with KPNB1 and Heart
 Blood Antibodies  >2 publications with KPNB1 and Blood
 Spleen Antibodies  >1 publications with KPNB1 and Spleen
 Pancreas Antibodies  >1 publications with KPNB1 and Pancreas
 Kidney Antibodies  >1 publications with KPNB1 and Kidney
 Eye Antibodies  >1 publications with KPNB1 and Eye
 Lung Antibodies  >1 publications with KPNB1 and Lung
 Testis Antibodies  >1 publications with KPNB1 and Testis
 Spinal Cord Antibodies  >1 publications with KPNB1 and Spinal Cord
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