NP_055666.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,617 Da
NCBI Official Full Name
kelch-like protein 21
NCBI Official Synonym Full Names
kelch-like family member 21
NCBI Protein Information
kelch-like protein 21; kelch-like 21
UniProt Protein Name
Kelch-like protein 21
UniProt Synonym Gene Names
UniProt Entry Name
KLH21_HUMAN
UniProt Comments for KLHL21
KLHL21: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1p36.31
Cellular Component: centrosome; cytoplasm; polar microtubule
Molecular Function: ubiquitin-protein ligase activity
Biological Process: mitosis; cell division; protein ubiquitination; regulation of cytokinesis
Research Articles on KLHL21
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Products associated with KLHL21 elisa kit
Pathways associated with KLHL21 elisa kit
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