NP_002275.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,501 Da
NCBI Official Full Name
keratin, type II cuticular Hb6
NCBI Official Synonym Full Names
keratin 86
NCBI Official Synonym Symbols
HB6; Hb1; MNX; hHb6; KRTHB1; KRTHB6 [Similar Products]
NCBI Protein Information
keratin, type II cuticular Hb6; K86; keratin-86; hair keratin K2.11; keratin protein HB6; type-II keratin Kb26; hard keratin, type II, 6; type II hair keratin Hb6; keratin, hair, basic, 6 (monilethrix)
UniProt Protein Name
Keratin, type II cuticular Hb6
UniProt Synonym Protein Names
Hair keratin K2.11; Keratin-86; K86; Type II hair keratin Hb6; Type-II keratin Kb26
UniProt Synonym Gene Names
UniProt Entry Name
KRT86_HUMAN
NCBI Summary for KRT86
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008]
UniProt Comments for KRT86
K86: Defects in KRT86 are a cause of monilethrix (MLTRX). Monilethrix is an autosomal dominant hair disorder characterized clinically by alopecia and follicular papules. Affected hairs have uniform elliptical nodes of normal thickness and intermittent constrictions, internodes at which the hair easily breaks. Usually only the scalp is involved, but in severe forms, the secondary sexual hair, eyebrows, eyelashes, and nails may also be affected. Belongs to the intermediate filament family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: extracellular space; keratin filament
Molecular Function: structural molecule activity
Disease: Monilethrix
Research Articles on KRT86
Precautions
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Diseases associated with KRT86 elisa kit
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