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KIF21A elisa kit :: Human kinesin family member 21A ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9334182 KIF21A elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,575 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,055 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

kinesin family member 21A (KIF21A), ELISA Kit

 Also Known As   

Human Kinesin-like protein KIF21A, KIF21A ELISA Kit

 Product Synonym Names    Human Kinesin-like protein KIF21A (KIF21A) ELISA kit; CFEOM; CFEOM1; DKFZp779C159; FEOM; FEOM1; FLJ20052; KIAA1708; Fibrosis of extraocular muscles; congenital; 1; autosomal dominant; KIF21A variant protein; NY-REN-62 antigen; fibrosis of the extraocular; kinesin family member 21A
 Product Gene Name   

KIF21A elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    608283
 3D Structure    ModBase 3D Structure for Q7Z4S6
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Other Notes    Small volumes of KIF21A elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for KIF21A purchase    MBS9334182 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the kinesin family member 21A (KIF21A) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KIF21A. The ELISA analytical biochemical technique of the MBS9334182 kit is based on KIF21A antibody-KIF21A antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KIF21A antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KIF21A. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for KIF21A. It may not necessarily be applicable to this product.
 NCBI GI #    291167760
 NCBI GeneID    55605
 NCBI Accession #    NP_001166934.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001173463.1 [Other Products]
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 UniProt Primary Accession #    Q7Z4S6 [Other Products]
 UniProt Secondary Accession #    Q2UVF1; Q6UKL9; Q7Z668; Q86WZ5; Q8IVZ8; Q9C0F5; A8MX28; B0I1R9; B9EGE4; F5H0C3; F5H219 [Other Products]
 UniProt Related Accession #    Q7Z4S6 [Other Products]
 Molecular Weight    187,179 Da
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 NCBI Official Full Name    kinesin-like protein KIF21A isoform 3
 NCBI Official Synonym Full Names    kinesin family member 21A
 NCBI Official Symbol    KIF21A [Similar Products]
 NCBI Official Synonym Symbols   
FEOM1; CFEOM1; FEOM3A
[Similar Products]
 NCBI Protein Information    kinesin-like protein KIF21A; renal carcinoma antigen NY-REN-62
 UniProt Protein Name    Kinesin-like protein KIF21A
 UniProt Synonym Protein Names   
Kinesin-like protein KIF2; Renal carcinoma antigen NY-REN-62
 Protein Family    Kinesin-like protein
 UniProt Gene Name    KIF21A [Similar Products]
 UniProt Synonym Gene Names    KIAA1708; KIF2 [Similar Products]
 UniProt Entry Name    KI21A_HUMAN
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 NCBI Summary for KIF21A    This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
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 UniProt Comments for KIF21A    KIF21A: Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity. Defects in KIF21A are a cause of congenital fibrosis of extraocular muscles type 1 (CFEOM1). CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM1 individuals show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. Belongs to the kinesin-like protein family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: kinesin complex; microtubule; cytoplasm

Molecular Function: protein binding; microtubule binding; ATPase activity; microtubule motor activity; ATP binding

Biological Process: metabolic process; microtubule-based movement

Disease: Fibrosis Of Extraocular Muscles, Congenital, 1
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 Research Articles on KIF21A    1. This study demonistrated that the interaction between Kif21a and Map1b is likely to play a critical role in the pathogenesis of CFEOM1 and highlights a selective vulnerability of the developing oculomotor nerve to perturbations of the axon cytoskeleton.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with KIF21A elisa kitOrgans/Tissues associated with KIF21A elisa kit
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >41 publications with KIF21A and Fibrosis
 Atrophy Antibodies  >3 publications with KIF21A and Atrophy
 Fibrosis of Extraocular Muscles, Congenital, 3B Antibodies  >2 publications with KIF21A and Fibrosis of Extraocular Muscles, Congenital, 3B
 Heart Defects, Congenital Antibodies  >1 publications with KIF21A and Heart Defects, Congenital
 Cardiovascular Diseases Antibodies  >1 publications with KIF21A and Cardiovascular Diseases
 Nerve Degeneration Antibodies  >1 publications with KIF21A and Nerve Degeneration
 Breast Neoplasms Antibodies  >1 publications with KIF21A and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with KIF21A and Cell Transformation, Neoplastic
 Adenocarcinoma Antibodies  >1 publications with KIF21A and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >36 publications with KIF21A and Muscle
 Eye Antibodies  >32 publications with KIF21A and Eye
 Nerve Antibodies  >25 publications with KIF21A and Nerve
 Brain Antibodies  >8 publications with KIF21A and Brain
 Blood Antibodies  >6 publications with KIF21A and Blood
 Lung Antibodies  >3 publications with KIF21A and Lung
 Heart Antibodies  >2 publications with KIF21A and Heart
 Embryonic Tissue Antibodies  >1 publications with KIF21A and Embryonic Tissue
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