NP_783864.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,808 Da
NCBI Official Full Name
beta-klotho
NCBI Official Synonym Full Names
klotho beta
NCBI Official Synonym Symbols
NCBI Protein Information
beta-klotho; betaKlotho; klotho beta like; klotho beta-like protein
UniProt Protein Name
Beta-klotho
UniProt Synonym Protein Names
Klotho beta-like protein
UniProt Synonym Gene Names
UniProt Entry Name
KLOTB_HUMAN
UniProt Comments for KLB
Klotho beta: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4p14
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding; fibroblast growth factor binding; hydrolase activity, hydrolyzing O-glycosyl compounds; fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; carbohydrate metabolic process; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response
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Products associated with KLB elisa kit
Pathways associated with KLB elisa kit
Diseases associated with KLB elisa kit
Organs/Tissues associated with KLB elisa kit
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