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L3MBTL elisa kit :: Human l (3) mbt-like (Drosophila) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9337773 L3MBTL elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

l (3) mbt-like (Drosophila) (L3MBTL), ELISA Kit

 Also Known As   

Human Lethal, L3MBTL ELISA Kit

 Product Synonym Names    Human Lethal (L3MBTL) ELISA kit; RP1-138B7.1; DKFZp586P1522; FLJ41181; H-L (3) MBT; KIAA0681; L3MBTL1; dJ138B7.3; l (3) mbt-like; lethal (3) malignant brain tumor l (3) ; l (3) mbt-like (Drosophila)
 Product Gene Name   

L3MBTL elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    608802
 3D Structure    ModBase 3D Structure for Q9Y468
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of L3MBTL elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for L3MBTL purchase    MBS9337773 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the l (3) mbt-like (Drosophila) (L3MBTL) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing L3MBTL. The ELISA analytical biochemical technique of the MBS9337773 kit is based on L3MBTL antibody-L3MBTL antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect L3MBTL antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, L3MBTL. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for L3MBTL. It may not necessarily be applicable to this product.
 NCBI GI #    117938328
 NCBI GeneID    26013
 NCBI Accession #    NP_056293.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_015478.6 [Other Products]
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 UniProt Primary Accession #    Q9Y468 [Other Products]
 UniProt Secondary Accession #    Q5H8Y8; Q5H8Y9; Q8IUV7; Q9H1E6; Q9H1G5; Q9UG06; Q9UJB9; Q9Y4C9; B4DRC9; E1P5W7 [Other Products]
 UniProt Related Accession #    Q9Y468 [Other Products]
 Molecular Weight    83,884 Da
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 NCBI Official Full Name    lethal(3)malignant brain tumor-like protein 1 isoform I
 NCBI Official Synonym Full Names    l(3)mbt-like 1 (Drosophila)
 NCBI Official Symbol    L3MBTL1 [Similar Products]
 NCBI Official Synonym Symbols   
L3MBTL; ZC2HC3; H-L(3)MBT; dJ138B7.3
[Similar Products]
 NCBI Protein Information    lethal(3)malignant brain tumor-like protein 1; lethal(3)malignant brain tumor-like protein 1; l(3)mbt protein homolog; lethal (3) malignant brain tumor l(3)
 UniProt Protein Name    Lethal(3)malignant brain tumor-like protein 1
 UniProt Synonym Protein Names   
L(3)mbt protein homolog; L3MBTL1
 UniProt Gene Name    L3MBTL1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0681; L3MBT; L3MBTL; H-l(3)mbt; H-l(3)mbt protein; L(3)mbt-like [Similar Products]
 UniProt Entry Name    LMBL1_HUMAN
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 NCBI Summary for L3MBTL    This gene represents a polycomb group gene. The encoded protein functions to regulate gene activity, likely via chromatin modification. The encoded protein may also be necessary for mitosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
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 UniProt Comments for L3MBTL    L3MBTL: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post- translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Histone-binding

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: nucleoplasm; plasma membrane; nucleolus; condensed chromosome; nucleus; chromatin

Molecular Function: identical protein binding; protein binding; nucleosomal histone binding; histone binding; zinc ion binding; nucleosome binding; SAM domain binding; chromatin binding; transcription factor activity; methylated histone residue binding

Biological Process: transcription, DNA-dependent; regulation of cell cycle; regulation of megakaryocyte differentiation; regulation of mitosis; hemopoiesis; chromatin modification; negative regulation of transcription, DNA-dependent
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 Research Articles on L3MBTL    1. Data indicate that germline genes, some of which drive oncogenesis in Drosophila melanogaster, are similarly ectopically activated in a wide range of human cancers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with L3MBTL elisa kitOrgans/Tissues associated with L3MBTL elisa kit
 Reference Product  PubMed Publications
 RB1 elisa kit  >1 publications with L3MBTL and RB1
 ETV7 elisa kit  >1 publications with L3MBTL and ETV7
 ETV6 elisa kit  >1 publications with L3MBTL and ETV6
 CBX3 elisa kit  >1 publications with L3MBTL and CBX3
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with L3MBTL and Brain
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