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LINGO1 elisa kit :: Human leucine rich repeat and Ig domain containing 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS941815
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (LIMIT 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,705 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,145 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

leucine rich repeat and Ig domain containing 1 (LINGO1), ELISA Kit

★Popular Item★
 Also Known As   

Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, LINGO1 ELISA Kit

 Product Synonym Names    Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) ELISA kit; FLJ14594; LERN1; LRRN6A; MGC17422; UNQ201; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine rich repeat and Ig domain containing 1
 Product Gene Name   

LINGO1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS941815 Testing Data    Testing Data PDF
 OMIM    609791
 3D Structure    ModBase 3D Structure for Q96FE5
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human LINGO1. No significant cross-reactivity or interference between human LINGO1 and analogues was observed.
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 Samples    serum, plasma, tissue homogenates, cell lysates
 Assay Type    Quantitative Sandwich
 Detection Range    0.312 ng/ml -20 ng/ml
 Sensitivity    <0.078 ng/ml.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of LINGO1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for LINGO1 purchase    MBS941815 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the leucine rich repeat and Ig domain containing 1 (LINGO1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.312 ng/ml -20 ng/ml in biological research samples containing LINGO1, with an estimated sensitivity of <0.078 ng/ml. The ELISA analytical biochemical technique of the MBS941815 kit is based on LINGO1 antibody-LINGO1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LINGO1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LINGO1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as serum, plasma, tissue homogenates, cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for LINGO1 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for LINGO1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any LINGO1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LINGO1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LINGO1 bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of LINGO1 elisa kit    LINGO1 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS941815. Click to request current manual
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NCBI/Uniprot data below describe general gene information for LINGO1. It may not necessarily be applicable to this product.
 NCBI GI #    50263044
 NCBI GeneID    84894
 NCBI Accession #    NP_116197.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_032808.6 [Other Products]
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 UniProt Primary Accession #    Q96FE5 [Other Products]
 UniProt Secondary Accession #    Q6NUK3; Q6UXM3; Q6VVG0; Q6VVG1; Q6VVG2; Q8N3K5; Q96K52; D3DW80 [Other Products]
 UniProt Related Accession #    Q96FE5 [Other Products]
 Molecular Weight    69,876 Da
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 NCBI Official Full Name    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a
 NCBI Official Synonym Full Names    leucine rich repeat and Ig domain containing 1
 NCBI Official Symbol    LINGO1 [Similar Products]
 NCBI Official Synonym Symbols   
LERN1; LRRN6A; UNQ201
[Similar Products]
 NCBI Protein Information    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1
 UniProt Protein Name    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
 UniProt Synonym Protein Names   
Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
 Protein Family    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
 UniProt Gene Name    LINGO1 [Similar Products]
 UniProt Synonym Gene Names    LERN1; LRRN6A; UNQ201/PRO227 [Similar Products]
 UniProt Entry Name    LIGO1_HUMAN
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 UniProt Comments for LINGO1    LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development
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 Research Articles on LINGO1    1. This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with LINGO1 elisa kitPathways associated with LINGO1 elisa kit
 Reference Product  PubMed Publications
 RTN4R elisa kit  >10 publications with LINGO1 and RTN4R
 NGFR elisa kit  >1 publications with LINGO1 and NGFR
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
 P75NTR Regulates Axonogenesis Pathway antibodies  P75NTR Regulates Axonogenesis Pathway Diagram
Diseases associated with LINGO1 elisa kitOrgans/Tissues associated with LINGO1 elisa kit
 Disease Name  Pubmed Publications
 Essential Tremor Antibodies  >27 publications with LINGO1 and Essential Tremor
 Inflammation Antibodies  >2 publications with LINGO1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with LINGO1 and Brain
 Embryonic Tissue Antibodies  >5 publications with LINGO1 and Embryonic Tissue
 Eye Antibodies  >4 publications with LINGO1 and Eye
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