NP_690852.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
70,861 Da
NCBI Official Full Name
leucine-rich repeat and WD repeat-containing protein 1
NCBI Official Synonym Full Names
leucine-rich repeats and WD repeat domain containing 1
NCBI Protein Information
leucine-rich repeat and WD repeat-containing protein 1; centromere protein 33; ORC-associated protein; origin recognition complex associated; origin recognition complex-associated protein
UniProt Protein Name
Leucine-rich repeat and WD repeat-containing protein 1
UniProt Synonym Protein Names
Centromere protein 33; CENP-33; Origin recognition complex-associated protein; ORC-associated protein; ORCA
UniProt Synonym Gene Names
UniProt Entry Name
LRWD1_HUMAN
UniProt Comments for LRWD1
LRWD1: Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors. Belongs to the LRWD1 family.
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: centric heterochromatin; cytoplasm; microtubule organizing center; nuclear origin of replication recognition complex; nucleus
Molecular Function: protein binding; methyl-CpG binding; chromatin binding; methylated histone residue binding
Biological Process: establishment and/or maintenance of chromatin architecture; DNA replication initiation; chromatin modification
Research Articles on LRWD1
Precautions
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Diseases associated with LRWD1 elisa kit
Organs/Tissues associated with LRWD1 elisa kit
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