NP_945347.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
52,992 Da
NCBI Official Full Name
lipase member I
NCBI Official Synonym Full Names
lipase, member I
NCBI Protein Information
lipase member I; LPD lipase; mPA-PLA1 beta; cancer/testis antigen 17; membrane-associated phospholipase A1 beta fl; membrane-associated phospholipase A1 beta 7B+; membrane-associated phospholipase A1 beta deltaE5; membrane-associated phospholipase A1 beta deltaE2-3; membrane-associated phospholipase A1 beta deltaE6.1; membrane-associated phospholipase A1 beta deltaE7.2; membrane-associated phospholipase A1 beta deltaE8-9; membrane-associated phosphatidic acid-selective phospholipase A1-beta
UniProt Protein Name
Lipase member I
UniProt Synonym Protein Names
Cancer/testis antigen 17; CT17; LPD lipase; Membrane-associated phosphatidic acid-selective phospholipase A1-beta; mPA-PLA1 beta
UniProt Synonym Gene Names
UniProt Entry Name
LIPI_HUMAN
NCBI Summary for LIPI
The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. The encoded protein, which can be inhibited by sodium vanadate, may be found exclusively in sperm. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. [provided by RefSeq, Jun 2010]
UniProt Comments for LIPI
LIPI: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). Defects in LIPI may be a cause of susceptibility to familial hypertriglyceridemia (FHTR)[MIM:145750]. Familial hypertriglyceridemia is a common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.1.-; Secreted, signal peptide; Phospholipase; Secreted; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 21q11.2
Cellular Component: extracellular space; membrane; extracellular region; plasma membrane
Molecular Function: heparin binding; phospholipase activity
Biological Process: lipid catabolic process
Disease: Hypertriglyceridemia, Familial
Research Articles on LIPI
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Diseases associated with LIPI elisa kit
Organs/Tissues associated with LIPI elisa kit
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