NP_001257916.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
46,709 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 3 isoform 2
NCBI Official Synonym Full Names
lymphotoxin beta receptor (TNFR superfamily, member 3)
NCBI Official Synonym Symbols
CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III [Similar Products]
NCBI Protein Information
tumor necrosis factor receptor superfamily member 3; lymphotoxin B receptor; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 3
UniProt Synonym Protein Names
Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
UniProt Synonym Gene Names
UniProt Entry Name
TNR3_HUMAN
NCBI Summary for LTBR
This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
UniProt Comments for LTBR
LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: integral to membrane
Molecular Function: identical protein binding; protein binding; ubiquitin protein ligase binding
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; positive regulation of JNK cascade; myeloid dendritic cell differentiation; signal transduction
Research Articles on LTBR
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Products associated with LTBR elisa kit
Pathways associated with LTBR elisa kit
Diseases associated with LTBR elisa kit
Organs/Tissues associated with LTBR elisa kit
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