NP_001269589.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
98,919 Da
NCBI Official Full Name
MKL/myocardin-like protein 1 isoform 1
NCBI Official Synonym Full Names
megakaryoblastic leukemia (translocation) 1
NCBI Protein Information
MKL/myocardin-like protein 1; Mkl1 variant 1 Mkl1_S; basic, SAP and coiled-coil domain; megakaryoblastic leukemia 1 protein; megakaryocytic acute leukemia protein; myocardin-related transcription factor A
UniProt Protein Name
MKL/myocardin-like protein 1
UniProt Synonym Protein Names
Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; Myocardin-related transcription factor A; MRTF-A
UniProt Synonym Gene Names
UniProt Entry Name
MKL1_HUMAN
NCBI Summary for MKL1
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for MKL1
MKL1: Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation. Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2. Ubiquitously expressed, has been detected in lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, muscle, heart and brain.
Protein type: Transcription, coactivator/corepressor; Oncoprotein
Chromosomal Location of Human Ortholog: 22q13
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: actin monomer binding; leucine zipper domain binding; protein binding; transcription coactivator activity; actin binding; transcription factor activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; negative regulation of caspase activity
Research Articles on MKL1
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Products associated with MKL1 elisa kit
Pathways associated with MKL1 elisa kit
Diseases associated with MKL1 elisa kit
Organs/Tissues associated with MKL1 elisa kit
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