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MLC1 elisa kit :: Human megalencephalic leukoencephalopathy with subcortical cysts 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9337225 MLC1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1), ELISA Kit

★Popular Item★
 Also Known As   

Human Membrane protein MLC1, MLC1 ELISA Kit

 Product Synonym Names    Human Membrane protein MLC1 (MLC1) ELISA kit; RP3-355C18.4; KIAA0027; LVM; MLC; VL; megalencephalic leukoencephalopathy with subcortical cysts 1 gene product; megalencephalic leukoencephalopathy with subcortical cysts 1
 Product Gene Name   

MLC1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    605908
 3D Structure    ModBase 3D Structure for Q15049
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Assay Type    Sandwich
 Detection Range    31.2 ng/ml - 1000 ng/ml.
 Sensitivity    The sensitivity of this kit is 5.0 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MLC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MLC1 purchase    MBS9337225 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.2 ng/ml - 1000 ng/ml in biological research samples containing MLC1, with an estimated sensitivity of The sensitivity of this kit is 5.0 ng/ml. The ELISA analytical biochemical technique of the MBS9337225 kit is based on MLC1 antibody-MLC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MLC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MLC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for MLC1 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MLC1 (hereafter termed this analyte) in undiluted original Human body fluids, tissue homogenates, secretions and feces samples.
Sample Manual Insert of MBS9337225. Click to request current manual
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NCBI/Uniprot data below describe general gene information for MLC1. It may not necessarily be applicable to this product.
 NCBI GI #    14589896
 NCBI GeneID    23209
 NCBI Accession #    NP_055981.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_015166.3 [Other Products]
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 UniProt Primary Accession #    Q15049 [Other Products]
 UniProt Secondary Accession #    Q5JZ83; Q8TAG4; Q96RP5; Q9UGY8; B3KW61; B7Z659 [Other Products]
 UniProt Related Accession #    Q15049 [Other Products]
 Molecular Weight    41,141 Da
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 NCBI Official Full Name    membrane protein MLC1
 NCBI Official Synonym Full Names    megalencephalic leukoencephalopathy with subcortical cysts 1
 NCBI Official Symbol    MLC1 [Similar Products]
 NCBI Official Synonym Symbols   
VL; LVM; MLC
[Similar Products]
 NCBI Protein Information    membrane protein MLC1
 UniProt Protein Name    Membrane protein MLC1
 Protein Family    Myosin
 UniProt Gene Name    MLC1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0027; WKL1 [Similar Products]
 UniProt Entry Name    MLC1_HUMAN
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 NCBI Summary for MLC1    The function of this gene product is unknown; however, homology to other proteins suggests that it may be an integral membrane transporter. Mutations in this gene have been associated with megalencephalic leukoencephalopathy with subcortical cysts, an autosomal recessive neurological disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MLC1    MLC1: Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. Defects in MLC1 are a cause of leukoencephalopathy megalencephalic with subcortical cysts type 1 (MLC1). MLC1 is a syndrome of cerebral leukoencephalopathy and megalencephaly characterized by ataxia, spasticity, seizures, delay in motor development and mild mental retardation. The brain appears swollen on magnetic resonance imaging, with diffuse white- matter abnormalities and the invariable presence of subcortical cysts in frontal and temporal lobes.

Protein type: Transporter; Membrane protein, multi-pass; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: clathrin-coated vesicle; endoplasmic reticulum; lysosome; basolateral plasma membrane; early endosome; integral to membrane; caveola; intercellular junction; lipid raft; recycling endosome; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; plasma membrane; cytoplasmic vesicle; endosome

Molecular Function: protein binding; transporter activity; protein complex binding; protein transporter activity

Biological Process: vesicle-mediated transport; protein transport; transport; positive regulation of intracellular transport; ion transport; protein oligomerization; regulation of response to osmotic stress

Disease: Megalencephalic Leukoencephalopathy With Subcortical Cysts 1
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 Research Articles on MLC1    1. results indicate GlialCAM is necessary for MLC1 protein expression, and its reduction affects the activity of volume-regulated anion currents (VRAC) which may cause astrocyte vacuolation; work extends the role of GlialCAM as a chaperone of MLC1 needed for proper VRAC activation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with MLC1 elisa kitOrgans/Tissues associated with MLC1 elisa kit
 Disease Name  Pubmed Publications
 Megalencephalic leukoencephalopathy with subcortical cysts Antibodies  >53 publications with MLC1 and Megalencephalic leukoencephalopathy with subcortical cysts
 Neoplasms Antibodies  >42 publications with MLC1 and Neoplasms
 Cardiovascular Diseases Antibodies  >32 publications with MLC1 and Cardiovascular Diseases
 Mental Disorders Antibodies  >30 publications with MLC1 and Mental Disorders
 Vascular Diseases Antibodies  >28 publications with MLC1 and Vascular Diseases
 Arterial Occlusive Diseases Antibodies  >16 publications with MLC1 and Arterial Occlusive Diseases
 Myocardial Ischemia Antibodies  >8 publications with MLC1 and Myocardial Ischemia
 Hypertension Antibodies  >3 publications with MLC1 and Hypertension
 Liver Diseases Antibodies  >2 publications with MLC1 and Liver Diseases
 Glioma Antibodies  >2 publications with MLC1 and Glioma
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >65 publications with MLC1 and Muscle
 Brain Antibodies  >48 publications with MLC1 and Brain
 Vascular Antibodies  >20 publications with MLC1 and Vascular
 Blood Antibodies  >18 publications with MLC1 and Blood
 Embryonic Tissue Antibodies  >13 publications with MLC1 and Embryonic Tissue
 Nerve Antibodies  >5 publications with MLC1 and Nerve
 Liver Antibodies  >3 publications with MLC1 and Liver
 Eye Antibodies  >2 publications with MLC1 and Eye
 Connective Tissue Antibodies  >1 publications with MLC1 and Connective Tissue
 Spleen Antibodies  >1 publications with MLC1 and Spleen
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