NP_005353.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
34,747 Da
NCBI Official Full Name
melanoma-associated antigen 3
NCBI Official Synonym Full Names
melanoma antigen family A, 3
NCBI Official Synonym Symbols
HIP8; HYPD; CT1.3; MAGE3; MAGEA6 [Similar Products]
NCBI Protein Information
melanoma-associated antigen 3; antigen MZ2-D; MAGE-3 antigen; cancer/testis antigen 1.3; cancer/testis antigen family 1, member 3
UniProt Protein Name
Melanoma-associated antigen 3
UniProt Synonym Protein Names
Antigen MZ2-D; Cancer/testis antigen 1.3; CT1.3; MAGE-3 antigen
UniProt Synonym Gene Names
UniProt Entry Name
MAGA3_HUMAN
NCBI Summary for MAGEA3
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]
UniProt Comments for MAGEA3
Function: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.1 PublicationManual assertion based on experiment in:Ref.9
Research Articles on MAGEA3
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Diseases associated with MAGEA3 elisa kit
Organs/Tissues associated with MAGEA3 elisa kit
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