NP_078820.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
39,800 Da
NCBI Official Full Name
mitochondrial ubiquitin ligase activator of NFKB 1
NCBI Official Synonym Full Names
mitochondrial E3 ubiquitin protein ligase 1
NCBI Official Synonym Symbols
GIDE; MAPL; MULAN; RNF218; C1orf166 [Similar Products]
NCBI Protein Information
mitochondrial ubiquitin ligase activator of NFKB 1; E3 ubiquitin ligase; ring finger protein 218; E3 SUMO-protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; mitochondrial E3 ubiquitin ligase 1; mitochondria-anchored protein ligase; growth inhibition and death E3 ligase; mitochondrial-anchored protein ligase; putative NF-kappa-B-activating protein 266; mitochondrial ubiquitin ligase activator of NF-kB
UniProt Protein Name
Mitochondrial ubiquitin ligase activator of NFKB 1
UniProt Synonym Protein Names
E3 SUMO-protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; Mitochondrial-anchored protein ligase; MAPL; Putative NF-kappa-B-activating protein 266; RING finger protein 218
UniProt Synonym Gene Names
UniProt Entry Name
MUL1_HUMAN
UniProt Comments for MUL1
MULAN: Exhibits weak E3 ubiquitin-protein ligase activity, but preferentially acts as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Protein type: EC 6.3.2.-; Ligase; EC 6.3.2.19; Mitochondrial; Membrane protein, integral; Apoptosis; Ubiquitin ligase; Ubiquitin conjugating system; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; peroxisome; integral to mitochondrial outer membrane
Molecular Function: identical protein binding; protein binding; signal transducer activity; zinc ion binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; SUMO ligase activity; ligase activity
Biological Process: caspase activation; mitochondrial fission; negative regulation of protein kinase B signaling cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; protein ubiquitination; negative regulation of defense response to virus by host; mitochondrion localization; activation of JNK activity; positive regulation of protein sumoylation; protein sumoylation; negative regulation of innate immune response; negative regulation of cell growth
Research Articles on MUL1
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Organs/Tissues associated with MUL1 elisa kit
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