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MCFD2 elisa kit :: Human multiple coagulation factor deficiency 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9327749 MCFD2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

multiple coagulation factor deficiency 2 (MCFD2), ELISA Kit

 Also Known As   

Human Multiple coagulation factor deficiency protein 2, MCFD2 ELISA Kit

 Product Synonym Names    Human Multiple coagulation factor deficiency protein 2 (MCFD2) ELISA kit; DKFZp686G21263; F5F8D; LMAN1IP; SDNSF; OTTHUMP00000203115; OTTHUMP00000203117; OTTHUMP00000203118; OTTHUMP00000203119; multiple coagulation factor deficiency protein 2; neural stem cell derived neuronal; multiple coagulation factor deficiency 2
 Product Gene Name   

MCFD2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 613625
 3D Structure    ModBase 3D Structure for Q8NI22
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MCFD2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MCFD2 purchase    MBS9327749 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the multiple coagulation factor deficiency 2 (MCFD2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MCFD2. The ELISA analytical biochemical technique of the MBS9327749 kit is based on MCFD2 antibody-MCFD2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MCFD2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MCFD2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for MCFD2. It may not necessarily be applicable to this product.
 NCBI GI #    284005451
 NCBI GeneID    90411
 NCBI Accession #    NP_001164977.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001171506.2 [Other Products]
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 UniProt Primary Accession #    Q8NI22 [Other Products]
 UniProt Secondary Accession #    Q53SS3; Q68D61; Q8N3M5; A8K7W2; D6W5A9; E9PD95 [Other Products]
 UniProt Related Accession #    Q8NI22 [Other Products]
 Molecular Weight    16,390 Da
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 NCBI Official Full Name    multiple coagulation factor deficiency protein 2 isoform A
 NCBI Official Synonym Full Names    multiple coagulation factor deficiency 2
 NCBI Official Symbol    MCFD2 [Similar Products]
 NCBI Official Synonym Symbols   
F5F8D; SDNSF; F5F8D2; LMAN1IP
[Similar Products]
 NCBI Protein Information    multiple coagulation factor deficiency protein 2; neural stem cell-derived neuronal survival protein
 UniProt Protein Name    Multiple coagulation factor deficiency protein 2
 UniProt Synonym Protein Names   
Neural stem cell-derived neuronal survival protein
 Protein Family    Multiple coagulation factor deficiency protein
 UniProt Gene Name    MCFD2 [Similar Products]
 UniProt Synonym Gene Names    SDNSF [Similar Products]
 UniProt Entry Name    MCFD2_HUMAN
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 NCBI Summary for MCFD2    This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]
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 UniProt Comments for MCFD2    MCFD2: The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors. Defects in MCFD2 are a cause of factor V and factor VIII combined deficiency type 2 (F5F8D2); also known as multiple coagulation factor deficiency 2 (MCFD2). F5F8D2 is a blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: Golgi apparatus; endoplasmic reticulum; ER-Golgi intermediate compartment

Molecular Function: calcium ion binding

Biological Process: vesicle-mediated transport; protein transport; cellular protein metabolic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

Disease: Factor V And Factor Viii, Combined Deficiency Of, 2
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 Research Articles on MCFD2    1. Studies indicate that the LMAN1-CRD contains distinct, separable binding sites for both its partner protein MCFD2 and the cargo proteins FV/FVIII.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MCFD2 elisa kitPathways associated with MCFD2 elisa kit
 Reference Product  PubMed Publications
 LMAN1 elisa kit  >42 publications with MCFD2 and LMAN1
 CTSZ elisa kit  >4 publications with MCFD2 and CTSZ
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Transport To The Golgi And Subsequent Modification Pathway antibodies  Transport To The Golgi And Subsequent Modification Pathway Diagram
Diseases associated with MCFD2 elisa kitOrgans/Tissues associated with MCFD2 elisa kit
 Disease Name  Pubmed Publications
 FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 2 Antibodies  >17 publications with MCFD2 and FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 2
 FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 1 Antibodies  >13 publications with MCFD2 and FACTOR V AND FACTOR VIII, COMBINED DEFICIENCY OF, 1
 Hemorrhage Antibodies  >7 publications with MCFD2 and Hemorrhage
 Disease Models, Animal Antibodies  >2 publications with MCFD2 and Disease Models, Animal
 Anemia Antibodies  >2 publications with MCFD2 and Anemia
 Ovarian Diseases Antibodies  >1 publications with MCFD2 and Ovarian Diseases
 Brain Diseases Antibodies  >1 publications with MCFD2 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >22 publications with MCFD2 and Blood
 Liver Antibodies  >2 publications with MCFD2 and Liver
 Ovary Antibodies  >1 publications with MCFD2 and Ovary
 Testis Antibodies  >1 publications with MCFD2 and Testis
 Brain Antibodies  >1 publications with MCFD2 and Brain
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