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MLL3 elisa kit :: Human myeloid/lymphoid or mixed-lineage leukemia 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9321421 MLL3 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), ELISA Kit

 Also Known As   

Human Histone-lysine N-methyltransferase MLL3, MLL3 ELISA Kit

 Product Synonym Names    Human Histone-lysine N-methyltransferase MLL3 (MLL3) ELISA kit; DKFZp686C08112; FLJ12625; FLJ38309; HALR; KIAA1506; KMT2C; MGC119851; MGC119852; MGC119853; ALR-like protein; histone-lysine N-methyltransferase; H3 lysine-4 specific; myeloid/lymphoid or mixed-lineage leukemia 3
 Product Gene Name   

MLL3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    606833
 3D Structure    ModBase 3D Structure for Q8NEZ4
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MLL3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MLL3 purchase    MBS9321421 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing MLL3. The ELISA analytical biochemical technique of the MBS9321421 kit is based on MLL3 antibody-MLL3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MLL3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MLL3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for MLL3. It may not necessarily be applicable to this product.
 NCBI GI #    91718902
 NCBI GeneID    58508
 NCBI Accession #    NP_733751.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_170606.2 [Other Products]
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 UniProt Primary Accession #    Q8NEZ4 [Other Products]
 UniProt Secondary Accession #    Q8NC02; Q8NDF6; Q9H9P4; Q9NR13; Q9P222; Q9UDR7 [Other Products]
 UniProt Related Accession #    Q8NEZ4 [Other Products]
 Molecular Weight    541,370 Da
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 NCBI Official Full Name    histone-lysine N-methyltransferase 2C
 NCBI Official Synonym Full Names    lysine (K)-specific methyltransferase 2C
 NCBI Official Symbol    KMT2C [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    histone-lysine N-methyltransferase 2C; ALR-like protein; homologous to ALR protein; histone-lysine N-methyltransferase MLL3; myeloid/lymphoid or mixed-lineage leukemia protein 3; histone-lysine N-methyltransferase, H3 lysine-4 specific
 UniProt Protein Name    Histone-lysine N-methyltransferase 2C
 UniProt Synonym Protein Names   
Homologous to ALR protein; Myeloid/lymphoid or mixed-lineage leukemia protein 3
 UniProt Gene Name    KMT2C [Similar Products]
 UniProt Synonym Gene Names    HALR; KIAA1506; MLL3; Lysine N-methyltransferase 2C [Similar Products]
 UniProt Entry Name    KMT2C_HUMAN
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 NCBI Summary for MLL3    This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MLL3    MLL3: a protein methyltransferase that methylates K4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation. Found in a critical region of chromosome 7, which is commonly deleted in malignant myeloid disorders. Partial duplication of the MLL3 gene are found in the juxtacentromeric region of chromosomes 1, 2, 13 and 21. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. MLL3 may be a catalytic subunit of this complex. Contributes to genome-scale circadian transcription. May be involved in leukemogenesis and developmental disorder. Highly expressed in testis and ovary, followed by brain and liver. Also expressed in placenta, peripherical blood, fetal thymus, heart, lung and kidney. Within brain, expression was highest in hippocampus, caudate nucleus, and substantia nigra. Not detected in skeletal muscle and fetal liver. Belongs to the protein lysine methyltransferase family. TRX/MLL subfamily. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase, protein lysine; EC; Methyltransferase

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: nucleoplasm; histone methyltransferase complex; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific)

Biological Process: establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; histone H3-K4 methylation
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 Research Articles on MLL3    1. Mll3 genetic variantsare associated with gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MLL3 elisa kitDiseases associated with MLL3 elisa kit
 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >18 publications with MLL3 and Neoplasms
 Breast Neoplasms Antibodies  >3 publications with MLL3 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3 publications with MLL3 and Adenocarcinoma
 Pregnancy Complications Antibodies  >2 publications with MLL3 and Pregnancy Complications
 Cognition Disorders Antibodies  >1 publications with MLL3 and Cognition Disorders
 Cell Transformation, Neoplastic Antibodies  >1 publications with MLL3 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with MLL3 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with MLL3 and Liver Diseases
 Carcinoma, Transitional Cell Antibodies  >1 publications with MLL3 and Carcinoma, Transitional Cell
 Cholangiocarcinoma Antibodies  >1 publications with MLL3 and Cholangiocarcinoma
Organs/Tissues associated with MLL3 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >6 publications with MLL3 and Liver
 Blood Antibodies  >5 publications with MLL3 and Blood
 Brain Antibodies  >4 publications with MLL3 and Brain
 Embryonic Tissue Antibodies  >3 publications with MLL3 and Embryonic Tissue
 Prostate Antibodies  >2 publications with MLL3 and Prostate
 Kidney Antibodies  >2 publications with MLL3 and Kidney
 Lung Antibodies  >2 publications with MLL3 and Lung
 Mammary Gland Antibodies  >2 publications with MLL3 and Mammary Gland
 Heart Antibodies  >2 publications with MLL3 and Heart
 Connective Tissue Antibodies  >1 publications with MLL3 and Connective Tissue
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