NP_061152.3
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
histone-lysine N-methyltransferase 2E
NCBI Official Synonym Full Names
lysine (K)-specific methyltransferase 2E
NCBI Protein Information
histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; myeloid/lymphoid or mixed-lineage leukemia protein 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
UniProt Protein Name
Histone-lysine N-methyltransferase 2E
UniProt Synonym Protein Names
Myeloid/lymphoid or mixed-lineage leukemia protein 5
UniProt Synonym Gene Names
UniProt Entry Name
KMT2E_HUMAN
NCBI Summary for KMT2E
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for KMT2E
MLL5: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.43; Transcription, coactivator/corepressor; Cell cycle regulation
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: nucleoplasm; intercellular bridge; intracellular membrane-bound organelle; cytoplasm; plasma membrane; nuclear speck
Molecular Function: protein binding; enzyme binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); transcription coactivator activity
Biological Process: retinoic acid receptor signaling pathway; establishment and/or maintenance of chromatin architecture; neutrophil activation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone H3-K4 methylation; positive regulation of granulocyte differentiation; neutrophil mediated immunity; DNA methylation; erythrocyte differentiation; cell cycle arrest
Research Articles on KMT2E
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with KMT2E elisa kit
Diseases associated with KMT2E elisa kit
Organs/Tissues associated with KMT2E elisa kit
|