NP_000251.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
254,390 Da
NCBI Official Full Name
unconventional myosin-VIIa isoform 1
NCBI Official Synonym Full Names
myosin VIIA
NCBI Official Synonym Symbols
DFNB2; MYU7A; NSRD2; USH1B; DFNA11; MYOVIIA [Similar Products]
NCBI Protein Information
unconventional myosin-VIIa; myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))
UniProt Protein Name
Unconventional myosin-VIIa
UniProt Synonym Gene Names
UniProt Entry Name
MYO7A_HUMAN
NCBI Summary for MYO7A
This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for MYO7A
MYO7A: an actin-based motor molecule with ATPase activity and a calcium sensitive calmodulin binding subunit. May play a role in trafficking of ribbon- synaptic vesicle complexes and renewal of outer photoreceptor disks. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. Seven alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: stereocilium; photoreceptor outer segment; photoreceptor inner segment; lysosomal membrane; apical plasma membrane; cytoplasm; melanosome; synapse; cell cortex; cytosol; photoreceptor connecting cilium
Molecular Function: microfilament motor activity; calmodulin binding; actin filament binding; protein domain specific binding; protein binding; protein homodimerization activity; spectrin binding; actin-dependent ATPase activity; ADP binding; ATP binding
Biological Process: phagolysosome formation; intracellular protein transport; eye photoreceptor cell development; sensory perception of sound; pigment granule transport; visual perception; lysosome organization and biogenesis; actin filament-based movement; metabolic process; sensory perception of light stimulus; auditory receptor cell stereocilium organization and biogenesis; equilibrioception; post-embryonic organ morphogenesis
Disease: Deafness, Autosomal Dominant 11; Deafness, Autosomal Recessive 2; Usher Syndrome, Type I
Research Articles on MYO7A
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Products associated with MYO7A elisa kit
Diseases associated with MYO7A elisa kit
Organs/Tissues associated with MYO7A elisa kit
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