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MTM1 elisa kit :: Human myotubularin 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9316983 MTM1 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

myotubularin 1 (MTM1), ELISA Kit

★Popular Item★
 Also Known As   

Human Myotubularin, MTM1 ELISA Kit

 Product Synonym Names    Human Myotubularin (MTM1) ELISA kit; CNM; MTMX; XLMTM; myotubularin; myotubularin 1
 Product Gene Name   

MTM1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    gene 310400
 3D Structure    ModBase 3D Structure for Q13496
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich (Quantitative)
 Detection Range    3.12 ng/ml - 100 ng/ml.
 Sensitivity    1.0 ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of MTM1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for MTM1 purchase    MBS9316983 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the myotubularin 1 (MTM1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12 ng/ml - 100 ng/ml in biological research samples containing MTM1, with an estimated sensitivity of 1.0 ng/ml. The ELISA analytical biochemical technique of the MBS9316983 kit is based on MTM1 antibody-MTM1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect MTM1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, MTM1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for MTM1 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MTM1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9316983. Click to request current manual
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NCBI/Uniprot data below describe general gene information for MTM1. It may not necessarily be applicable to this product.
 NCBI GI #    4557896
 NCBI GeneID    4534
 NCBI Accession #    NP_000243.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000252.2 [Other Products]
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 UniProt Primary Accession #    Q13496 [Other Products]
 UniProt Secondary Accession #    Q8NEL1; A6NDB1 [Other Products]
 UniProt Related Accession #    Q13496 [Other Products]
 Molecular Weight    69,932 Da
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 NCBI Official Full Name    myotubularin
 NCBI Official Synonym Full Names    myotubularin 1
 NCBI Official Symbol    MTM1 [Similar Products]
 NCBI Official Synonym Symbols   
CNM; MTMX; XLMTM
[Similar Products]
 NCBI Protein Information    myotubularin
 UniProt Protein Name    Myotubularin
 Protein Family    Myotubularin
 UniProt Gene Name    MTM1 [Similar Products]
 UniProt Synonym Gene Names    CG2 [Similar Products]
 UniProt Entry Name    MTM1_HUMAN
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 NCBI Summary for MTM1    This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MTM1    MTM1: Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine- containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. Defects in MTM1 are the cause of centronuclear myopathy X-linked (CNMX). A congenital muscle disorder characterized by progressive muscular. weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Protein type: Protein phosphatase, dual-specificity; EC 3.1.3.95; EC 3.1.3.64; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: ruffle; I band; cytoplasm; late endosome; plasma membrane; cytosol; filopodium

Molecular Function: phosphatidylinositol-3-phosphatase activity; protein binding; intermediate filament binding; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; phosphoinositide binding

Biological Process: muscle maintenance; protein transport; phospholipid metabolic process; phosphatidylinositol biosynthetic process; endosome to lysosome transport; intermediate filament organization; phosphoinositide dephosphorylation; protein amino acid dephosphorylation; mitochondrion distribution

Disease: Myopathy, Centronuclear, X-linked
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 Research Articles on MTM1    1. Mutations in specific myotubularins such as MTM1 result in myotubular myopathy and Charcot-Marie-Tooth peripheral neuropathy. (Review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MTM1 elisa kitDiseases associated with MTM1 elisa kit
 Products by Pathway  Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >99 publications with MTM1 and Nervous System Diseases
 Muscular Diseases Antibodies  >91 publications with MTM1 and Muscular Diseases
 MYOPATHY, CENTRONUCLEAR, X-LINKED Antibodies  >51 publications with MTM1 and MYOPATHY, CENTRONUCLEAR, X-LINKED
 Muscle Weakness Antibodies  >47 publications with MTM1 and Muscle Weakness
 Brain Diseases Antibodies  >3 publications with MTM1 and Brain Diseases
 Peripheral Nervous System Diseases Antibodies  >3 publications with MTM1 and Peripheral Nervous System Diseases
 Central Nervous System Diseases Antibodies  >3 publications with MTM1 and Central Nervous System Diseases
 Hypertrophy Antibodies  >3 publications with MTM1 and Hypertrophy
 Eye Diseases Antibodies  >3 publications with MTM1 and Eye Diseases
 Mental Disorders Antibodies  >2 publications with MTM1 and Mental Disorders
Organs/Tissues associated with MTM1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >89 publications with MTM1 and Muscle
 Embryonic Tissue Antibodies  >5 publications with MTM1 and Embryonic Tissue
 Brain Antibodies  >5 publications with MTM1 and Brain
 Blood Antibodies  >4 publications with MTM1 and Blood
 Pancreas Antibodies  >2 publications with MTM1 and Pancreas
 Lung Antibodies  >2 publications with MTM1 and Lung
 Bone Antibodies  >1 publications with MTM1 and Bone
 Kidney Antibodies  >1 publications with MTM1 and Kidney
 Eye Antibodies  >1 publications with MTM1 and Eye
 Bone Marrow Antibodies  >1 publications with MTM1 and Bone Marrow
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