NP_001160132.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,895 Da
NCBI Official Full Name
neuroligin-3 isoform 3
NCBI Official Synonym Full Names
neuroligin 3
NCBI Official Synonym Symbols
NCBI Protein Information
neuroligin-3; gliotactin homolog
UniProt Protein Name
Neuroligin-3
UniProt Synonym Protein Names
Gliotactin homolog
UniProt Synonym Gene Names
UniProt Entry Name
NLGN3_HUMAN
NCBI Summary for NLGN3
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]
UniProt Comments for NLGN3
NLGN3: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1). AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1). ASPGX1 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq13.1
Cellular Component: extracellular space; cell surface; endocytic vesicle; integral to plasma membrane; excitatory synapse; synapse; cell junction
Molecular Function: protein binding; neurexin binding; receptor activity; cell adhesion molecule binding
Biological Process: regulation of synaptic transmission; receptor-mediated endocytosis; rhythmic synaptic transmission; axon extension; metabolic process; neurological control of breathing; social behavior; learning; positive regulation of synaptic transmission, glutamatergic; regulation of inhibitory postsynaptic membrane potential; positive regulation of synaptogenesis; synaptogenesis; adult behavior; synapse organization and biogenesis; visual learning; oligodendrocyte differentiation; neuron adhesion
Disease: Asperger Syndrome, X-linked, Susceptibility To, 1; Autism, Susceptibility To, X-linked 1
Research Articles on NLGN3
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Products associated with NLGN3 elisa kit
Pathways associated with NLGN3 elisa kit
Diseases associated with NLGN3 elisa kit
Organs/Tissues associated with NLGN3 elisa kit
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