NP_001276928.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,472 Da
NCBI Official Full Name
nuclear factor interleukin-3-regulated protein
NCBI Official Synonym Full Names
nuclear factor, interleukin 3 regulated
NCBI Protein Information
nuclear factor interleukin-3-regulated protein; E4 promoter-binding protein 4; interleukin-3-binding protein 1; transcriptional activator NF-IL3A; nuclear factor interleukin 3 regulated protein; interleukin-3 promoter transcriptional activator
UniProt Protein Name
Nuclear factor interleukin-3-regulated protein
UniProt Synonym Protein Names
E4 promoter-binding protein 4; Interleukin-3 promoter transcriptional activator; Interleukin-3-binding protein 1; Transcriptional activator NF-IL3A
UniProt Synonym Gene Names
UniProt Entry Name
NFIL3_HUMAN
NCBI Summary for NFIL3
The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
UniProt Comments for NFIL3
E4BP4: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B- site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Belongs to the bZIP family. NFIL3 subfamily.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor activity; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; circadian rhythm; immune response; negative regulation of transcription from RNA polymerase II promoter
Research Articles on NFIL3
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Products associated with NFIL3 elisa kit
Diseases associated with NFIL3 elisa kit
Organs/Tissues associated with NFIL3 elisa kit
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