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NR1H2 elisa kit :: Human nuclear receptor subfamily 1, group H, member 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS701505
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
24-Strip-Wells (Limit 1)  /  $250 +1 FREE 8GB USB
48-Strip-Wells  /  $550 +1 FREE 8GB USB
96-Strip-Wells  /  $795 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,890 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,465 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

nuclear receptor subfamily 1, group H, member 2 (NR1H2), ELISA Kit

★Popular Item★
 Also Known As   

Human Liver X Receptor beta, LXRbeta ELISA Kit

 Product Synonym Names    Human Liver X Receptor beta (LXRbeta) ELISA Kit; LXR-b; LXRB; NER; NER-I; RIP15; UNR; LX receptor beta; liver X receptor beta; liver X receptor-beta; nuclear orphan receptor LXR-beta; oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; u; nuclear receptor subfamily 1; group H; member 2
 Product Gene Name   

NR1H2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 MBS701505 Testing Data    Testing Data PDF
 OMIM    600380
 3D Structure    ModBase 3D Structure for P55055
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of Human NR1H2. No significant cross-reactivity or interference between Human NR1H2 and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates, Cell lysates
 Assay Type    Sandwich
 Detection Range    31.25 pg/ml-2000 pg/ml
 Sensitivity    7.81 pg/ml
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV% is less than 8%
Three samples of known concentration were tested twenty times on one plate to assess.
Inter-assay Precision (Precision between assays): CV% is less than 10%
Three samples of known concentration were tested in twenty assays to assess.
 Detection Wavelength    450 nm
 Sample Volume    50-100ul
 Protein Biological Process 1    Transcription/Transcription regulation
 Protein Biological Process 3    Transcription
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NR1H2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NR1H2 purchase    MBS701505 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the nuclear receptor subfamily 1, group H, member 2 (NR1H2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 31.25 pg/ml-2000 pg/ml in biological research samples containing NR1H2, with an estimated sensitivity of 7.81 pg/ml. The ELISA analytical biochemical technique of the MBS701505 kit is based on NR1H2 antibody-NR1H2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NR1H2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NR1H2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates, Cell lysates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for NR1H2 elisa kit

   Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for LXRbeta has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any LXRbeta present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LXRbeta is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LXRbeta bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of NR1H2 elisa kit    NR1H2 elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS701505. Click to request current manual
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NCBI/Uniprot data below describe general gene information for NR1H2. It may not necessarily be applicable to this product.
 NCBI GI #    375331888
 NCBI GeneID    7376
 NCBI Accession #    NP_001243576.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256647.1 [Other Products]
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 UniProt Primary Accession #    P55055 [Other Products]
 UniProt Secondary Accession #    Q12970; Q5I0Y1; A8K490; B4DNM6; E7EWA6 [Other Products]
 UniProt Related Accession #    P55055 [Other Products]
 Molecular Weight    50,974 Da
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 NCBI Official Full Name    oxysterols receptor LXR-beta isoform 2
 NCBI Official Synonym Full Names    nuclear receptor subfamily 1, group H, member 2
 NCBI Official Symbol    NR1H2 [Similar Products]
 NCBI Official Synonym Symbols   
NER; UNR; LXRB; LXR-b; NER-I; RIP15
[Similar Products]
 NCBI Protein Information    oxysterols receptor LXR-beta; LX receptor beta; nuclear receptor NER; liver X nuclear receptor beta; nuclear orphan receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor
 UniProt Protein Name    Oxysterols receptor LXR-beta
 UniProt Synonym Protein Names   
Liver X receptor beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; Ubiquitously-expressed nuclear receptor
 Protein Family    Oxysterols receptor
 UniProt Gene Name    NR1H2 [Similar Products]
 UniProt Synonym Gene Names    LXRB; NER; UNR [Similar Products]
 UniProt Entry Name    NR1H2_HUMAN
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 NCBI Summary for NR1H2    The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
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 UniProt Comments for NR1H2    Function: Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism
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 Research Articles on NR1H2    1. structural analysis of human retinoid X receptor alpha-liver X receptor beta (RXRalpha-LXRbeta) heterodimer on its cognate element, an AGGTCA direct repeat spaced by 4 nt
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NR1H2 elisa kitPathways associated with NR1H2 elisa kit
 Reference Product  PubMed Publications
 ABCA1 elisa kit  >8 publications with NR1H2 and ABCA1
 PPARG elisa kit  >2 publications with NR1H2 and PPARG
 NR0B2 elisa kit  >2 publications with NR1H2 and NR0B2
 PPARA elisa kit  >1 publications with NR1H2 and PPARA
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
Diseases associated with NR1H2 elisa kitOrgans/Tissues associated with NR1H2 elisa kit
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >9 publications with NR1H2 and Liver Diseases
 Fatty Liver Antibodies  >8 publications with NR1H2 and Fatty Liver
 Atherosclerosis Antibodies  >6 publications with NR1H2 and Atherosclerosis
 Inflammation Antibodies  >6 publications with NR1H2 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with NR1H2 and Cardiovascular Diseases
 Hypercholesterolemia Antibodies  >4 publications with NR1H2 and Hypercholesterolemia
 Dyslipidemias Antibodies  >3 publications with NR1H2 and Dyslipidemias
 Insulin Resistance Antibodies  >3 publications with NR1H2 and Insulin Resistance
 Hyperlipidemias Antibodies  >2 publications with NR1H2 and Hyperlipidemias
 Hypertriglyceridemia Antibodies  >2 publications with NR1H2 and Hypertriglyceridemia
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >37 publications with NR1H2 and Liver
 Brain Antibodies  >6 publications with NR1H2 and Brain
 Blood Antibodies  >4 publications with NR1H2 and Blood
 Thyroid Antibodies  >3 publications with NR1H2 and Thyroid
 Pancreas Antibodies  >3 publications with NR1H2 and Pancreas
 Kidney Antibodies  >2 publications with NR1H2 and Kidney
 Skin Antibodies  >2 publications with NR1H2 and Skin
 Bladder Antibodies  >1 publications with NR1H2 and Bladder
 Prostate Antibodies  >1 publications with NR1H2 and Prostate
 Intestine Antibodies  >1 publications with NR1H2 and Intestine
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