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NR1I2 elisa kit :: Human nuclear receptor subfamily 1, group I, member 2 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9326391 NR1I2 elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

nuclear receptor subfamily 1, group I, member 2 (NR1I2), ELISA Kit

★Popular Item★
 Also Known As   

Human Nuclear receptor subfamily 1 group I member 2, NR1I2 ELISA Kit

 Product Synonym Names    Human Nuclear receptor subfamily 1 group I member 2 (NR1I2) ELISA kit; BXR; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; SAR; SXR; orphan nuclear receptor PXR; steroid and xenobiotic receptor; nuclear receptor subfamily 1; group I; member 2
 Product Gene Name   

NR1I2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    603065
 3D Structure    ModBase 3D Structure for O75469
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Undiluted original Human body fluids, tissue homogenates, secretions or feces samples.
 Assay Type    Sandwich (Quantitative)
 Detection Range    62.5 pg/ml - 2000 pg/ml.
 Sensitivity    10 pg/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%.
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of NR1I2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for NR1I2 purchase    MBS9326391 is a ready-to-use microwell, strip plate Sandwich (Quantitative) ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the nuclear receptor subfamily 1, group I, member 2 (NR1I2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 62.5 pg/ml - 2000 pg/ml in biological research samples containing NR1I2, with an estimated sensitivity of 10 pg/ml. The ELISA analytical biochemical technique of the MBS9326391 kit is based on NR1I2 antibody-NR1I2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect NR1I2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, NR1I2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for NR1I2 elisa kit

   Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NR1I2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9326391. Click to request current manual
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NCBI/Uniprot data below describe general gene information for NR1I2. It may not necessarily be applicable to this product.
 NCBI GI #    34398348
 NCBI GeneID    8856
 NCBI Accession #    NP_003880.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003889.3 [Other Products]
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 UniProt Primary Accession #    O75469 [Other Products]
 UniProt Secondary Accession #    Q006P5; Q008C8; Q96AC7; Q9UJ22; Q9UJ23; Q9UJ24; Q9UJ25; Q9UJ26; Q9UJ27; Q9UNW4 [Other Products]
 UniProt Related Accession #    O75469 [Other Products]
 Molecular Weight    49,762 Da
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 NCBI Official Full Name    nuclear receptor subfamily 1 group I member 2 isoform 1
 NCBI Official Synonym Full Names    nuclear receptor subfamily 1, group I, member 2
 NCBI Official Symbol    NR1I2 [Similar Products]
 NCBI Official Synonym Symbols   
BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 1 group I member 2; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X nuclear receptor variant 2
 UniProt Protein Name    Nuclear receptor subfamily 1 group I member 2
 UniProt Synonym Protein Names   
Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
 Protein Family    Nuclear receptor subfamily
 UniProt Gene Name    NR1I2 [Similar Products]
 UniProt Synonym Gene Names    PXR; SXR [Similar Products]
 UniProt Entry Name    NR1I2_HUMAN
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 NCBI Summary for NR1I2    This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NR1I2    PXR: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. Heterodimer with RXR. Interacts with NCOA1. Expressed in liver, colon and small intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 3q12-q13.3

Cellular Component: nucleoplasm

Molecular Function: ligand-dependent nuclear receptor activity; protein binding; zinc ion binding; transcription coactivator activity; steroid hormone receptor activity; drug binding

Biological Process: steroid metabolic process; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; positive regulation of transcription, DNA-dependent; drug export; signal transduction; xenobiotic metabolic process; exogenous drug catabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; xenobiotic transport; steroid hormone mediated signaling; negative regulation of transcription, DNA-dependent
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 Research Articles on NR1I2    1. Data suggest that post-transcriptional and post-translational modifications of PXR are critical in regulation of xenobiotic-metabolizing cytochrome P450 enzymes, mainly in hepatic tissue. [REVIEW]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NR1I2 elisa kitPathways associated with NR1I2 elisa kit
 Reference Product  PubMed Publications
 NCOA1 elisa kit  >2 publications with NR1I2 and NCOA1
 RXRG elisa kit  >1 publications with NR1I2 and RXRG
 RXRB elisa kit  >1 publications with NR1I2 and RXRB
 RXRA elisa kit  >1 publications with NR1I2 and RXRA
 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
Diseases associated with NR1I2 elisa kitOrgans/Tissues associated with NR1I2 elisa kit
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >14 publications with NR1I2 and Neoplasms
 Drug Toxicity Antibodies  >13 publications with NR1I2 and Drug Toxicity
 Gastrointestinal Diseases Antibodies  >13 publications with NR1I2 and Gastrointestinal Diseases
 Liver Diseases Antibodies  >10 publications with NR1I2 and Liver Diseases
 Carcinoma Antibodies  >9 publications with NR1I2 and Carcinoma
 Cholestasis Antibodies  >8 publications with NR1I2 and Cholestasis
 Adenocarcinoma Antibodies  >6 publications with NR1I2 and Adenocarcinoma
 Inflammation Antibodies  >6 publications with NR1I2 and Inflammation
 Liver Neoplasms Antibodies  >5 publications with NR1I2 and Liver Neoplasms
 Cholestasis, Intrahepatic Antibodies  >4 publications with NR1I2 and Cholestasis, Intrahepatic
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >54 publications with NR1I2 and Liver
 Intestine Antibodies  >17 publications with NR1I2 and Intestine
 Bone Marrow Antibodies  >1 publications with NR1I2 and Bone Marrow
 Stomach Antibodies  >1 publications with NR1I2 and Stomach
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