NP_001020750.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,375 Da
NCBI Official Full Name
nuclear distribution protein nudE-like 1 isoform A
NCBI Official Synonym Full Names
nudE neurodevelopment protein 1-like 1
NCBI Official Synonym Symbols
EOPA; NDE2; NUDEL; MITAP1; NDE1L1 [Similar Products]
NCBI Protein Information
nuclear distribution protein nudE-like 1; protein Nudel; endooligopeptidase A; mitosin-associated protein 1; mitosin-associated protein MITAP1; nudE nuclear distribution E homolog-like 1; nudE nuclear distribution gene E homolog-like 1
UniProt Protein Name
Nuclear distribution protein nudE-like 1
UniProt Synonym Protein Names
Mitosin-associated protein 1
UniProt Synonym Gene Names
UniProt Entry Name
NDEL1_HUMAN
NCBI Summary for NDEL1
This gene encodes a coiled-coil protein that plays a role in multiple processes including cytoskeletal organization, cell signaling and neuron migration, outgrowth and maintenance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Mar 2012]
UniProt Comments for NDEL1
NDEL1: Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. Belongs to the nudE family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Microtubule-binding; Protease
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: kinetochore; axon hillock; kinesin complex; microtubule; centrosome; neurofilament cytoskeleton; cytoplasm; leading edge; nucleolus; nuclear envelope; spindle; cytosol
Molecular Function: protein binding; microtubule binding; beta-tubulin binding; alpha-tubulin binding
Biological Process: positive regulation of axon regeneration; cell migration; central nervous system neuron axonogenesis; positive regulation of axon extension; neuron migration; establishment of chromosome localization; nuclear envelope disassembly; proteolysis; microtubule nucleation; retrograde axon cargo transport; inner cell mass cell proliferation; chromosome segregation; mitotic centrosome separation; establishment of mitotic spindle orientation; neurofilament cytoskeleton organization and biogenesis; centrosome localization; vesicle transport along microtubule; cerebral cortex radially oriented cell migration; mitotic cell cycle
Research Articles on NDEL1
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Products associated with NDEL1 elisa kit
Pathways associated with NDEL1 elisa kit
Diseases associated with NDEL1 elisa kit
Organs/Tissues associated with NDEL1 elisa kit
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