NP_000266.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
92,850 Da
NCBI Official Full Name
P protein isoform 1
NCBI Official Synonym Full Names
oculocutaneous albinism II
NCBI Official Synonym Symbols
P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12 [Similar Products]
NCBI Protein Information
P protein; eye color 3 (brown); hair color 3 (brown); eye color 2 (central brown); total brown iris pigmentation; pink-eyed dilution protein homolog; melanocyte-specific transporter protein; oculocutaneous albinism II (pink-eye dilution homolog, mouse)
UniProt Protein Name
P protein
UniProt Synonym Protein Names
Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog
UniProt Synonym Gene Names
UniProt Entry Name
P_HUMAN
NCBI Summary for OCA2
This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Comments for OCA2
OCA2: a transporer of tyrosine, a precursor for melanin synthesis, within melanocytes. Regulates the pH of melanosomes and melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the SLC13A transporter family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter
Chromosomal Location of Human Ortholog: 15q
Cellular Component: endoplasmic reticulum membrane; lysosomal membrane; cytoplasm; melanosome membrane; integral to membrane; endosome membrane
Molecular Function: protein binding; transporter activity; L-tyrosine transmembrane transporter activity
Biological Process: melanin biosynthetic process; cell proliferation; tyrosine transport; melanocyte differentiation; eye pigment biosynthetic process; transmembrane transport; spermatid development
Disease: Albinism, Oculocutaneous, Type Ii; Skin/hair/eye Pigmentation, Variation In, 1
Research Articles on OCA2
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Pathways associated with OCA2 elisa kit
Diseases associated with OCA2 elisa kit
Organs/Tissues associated with OCA2 elisa kit
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