AAH25282.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,072 Da
NCBI Official Full Name
P21 protein (Cdc42/Rac)-activated kinase 4
NCBI Official Synonym Full Names
p21 protein (Cdc42/Rac)-activated kinase 4
NCBI Protein Information
serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
UniProt Protein Name
Serine/threonine-protein kinase PAK 4
UniProt Synonym Protein Names
p21-activated kinase 4
UniProt Synonym Gene Names
UniProt Entry Name
PAK4_HUMAN
NCBI Summary for PAK4
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PAK4
PAK4: a protein kinase of the STE20 family. A mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Interacts specifically with the GTP-bound form of Cdc42 and weakly activates the JNK family of MAP kinases. Overexpressed in several cancers. Required for ras-dependent anchorage-independent growth of tumor cell lines. Four alternatively spliced human isoforms have been reported.
Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKB subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: Golgi apparatus; focal adhesion
Molecular Function: protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity
Biological Process: cell proliferation; cell migration; apoptosis; cytoskeleton organization and biogenesis; mitotic cell cycle; signal transduction; cell motility; cell growth; protein amino acid phosphorylation
Research Articles on PAK4
Precautions
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Pathways associated with PAK4 elisa kit
Diseases associated with PAK4 elisa kit
Organs/Tissues associated with PAK4 elisa kit
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