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PAX6 elisa kit :: Human paired box 6 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9321784 PAX6 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

paired box 6 (PAX6), ELISA Kit

★Popular Item★
 Also Known As   

Human Paired box protein Pax-6, PAX6 ELISA Kit

 Product Synonym Names    Human Paired box protein Pax-6 (PAX6) ELISA kit; AN; AN2; D11S812E; MGC17209; MGDA; WAGR; OTTHUMP00000038834; OTTHUMP00000038836; OTTHUMP00000038837; OTTHUMP00000038838; OTTHUMP00000038839; OTTHUMP00000038840; paired box gene 6; paired box homeotic gene-; paired box 6
 Product Gene Name   

PAX6 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Sample Manual Insert    Download PDF Manual View PDF Manual
 Request for Current Manual Insert    Request Current Manual
 OMIM    607108
 3D Structure    ModBase 3D Structure for P26367
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 Species Reactivity    Human
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 Specificity    No significant cross-reactivity or interference between this analyte and analogues is observed.
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 Samples    Body fluids, tissue homogenates, secretions or feces samples
 Assay Type    Quantitative Sandwich
 Detection Range    0.25ng/ml-8ng/ml
 Sensitivity    0.1ng/ml.
 Intra-assay Precision    Intra-assay CV (%) is less than 15%
 Inter-assay Precision    Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean 100].
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PAX6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PAX6 purchase    MBS9321784 is a ready-to-use microwell, strip plate Quantitative Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the paired box 6 (PAX6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 0.25ng/ml-8ng/ml in biological research samples containing PAX6, with an estimated sensitivity of 0.1ng/ml. The ELISA analytical biochemical technique of the MBS9321784 kit is based on PAX6 antibody-PAX6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PAX6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PAX6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions such as Body fluids, tissue homogenates, secretions or feces samples. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Related Product Information for PAX6 elisa kit

   Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PAX6 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Sample Manual Insert of MBS9321784. Click to request current manual
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NCBI/Uniprot data below describe general gene information for PAX6. It may not necessarily be applicable to this product.
 NCBI GI #    4505615
 NCBI GeneID    5080
 NCBI Accession #    NP_000271.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000280.4 [Other Products]
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 UniProt Primary Accession #    P26367 [Other Products]
 UniProt Secondary Accession #    Q6N006; Q99413 [Other Products]
 Molecular Weight    46,683 Da
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 NCBI Official Full Name    paired box protein Pax-6 isoform a
 NCBI Official Synonym Full Names    paired box 6
 NCBI Official Symbol    PAX6 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    paired box protein Pax-6; oculorhombin; aniridia type II protein; paired box homeotic gene-6
 UniProt Protein Name    Paired box protein Pax-6
 UniProt Synonym Protein Names   
Aniridia type II protein; Oculorhombin
 Protein Family    Paired box protein
 UniProt Gene Name    PAX6 [Similar Products]
 UniProt Synonym Gene Names    AN2 [Similar Products]
 UniProt Entry Name    PAX6_HUMAN
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 NCBI Summary for PAX6    This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for PAX6    PAX6: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Isoform 5a appears to function as a molecular switch that specifies target genes. Defects in PAX6 are the cause of aniridia (AN). A congenital, bilateral, panocular disorder characterized by complete absence of the iris or extreme iris hypoplasia. Aniridia is not just an isolated defect in iris development but it is associated with macular and optic nerve hypoplasia, cataract, corneal changes, nystagmus. Visual acuity is generally low but is unrelated to the degree of iris hypoplasia. Glaucoma is a secondary problem causing additional visual loss over time. Defects in PAX6 are a cause of Peters anomaly (PAN). Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea. Defects in PAX6 are a cause of foveal hypoplasia (FOVHYP). Foveal hypoplasia can be isolated or associated with presenile cataract. Inheritance is autosomal dominant. Defects in PAX6 are a cause of keratitis hereditary (KERH). An ocular disorder characterized by corneal opacification, recurrent stromal keratitis and vascularization. Defects in PAX6 are a cause of coloboma of iris choroid and retina (COI); also known as uveoretinal coloboma. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Severe colobomatous malformations may cause as much as 10% of the childhood blindness. The clinical presentation of ocular coloboma is variable. Some individuals may present with minimal defects in the anterior iris leaf without other ocular defects. More complex malformations create a combination of iris, uveoretinal and/or optic nerve defects without or with microphthalmia or even anophthalmia. Defects in PAX6 are a cause of coloboma of optic nerve (COLON). Defects in PAX6 are a cause of bilateral optic nerve hypoplasia (BONH); also known as bilateral optic nerve aplasia. A congenital anomaly in which the optic disc appears abnormally small. It may be an isolated finding or part of a spectrum of anatomic and functional abnormalities that includes partial or complete agenesis of the septum pellucidum, other midline brain defects, cerebral anomalies, pituitary dysfunction, and structural abnormalities of the pituitary. Defects in PAX6 are a cause of aniridia cerebellar ataxia and mental deficiency (ACAMD); also known as Gillespie syndrome. A rare condition consisting of partial rudimentary iris, cerebellar impairment of the ability to perform coordinated voluntary movements, and mental retardation. Belongs to the paired homeobox family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: nucleoplasm; cytoplasm; nuclear chromatin; nucleus

Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; AT DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; ubiquitin-protein ligase activity; chromatin binding; transcription factor activity; transcription factor binding; protein kinase binding

Biological Process: central nervous system development; positive regulation of transcription, DNA-dependent; protein ubiquitination; cell fate determination; glucose homeostasis; cerebellum development; positive regulation of epithelial cell differentiation; neural crest cell migration; positive regulation of neuroblast proliferation; positive regulation of cell fate specification; neuron fate commitment; oligodendrocyte cell fate specification; interkinetic nuclear migration; keratinocyte differentiation; forebrain-midbrain boundary formation; negative regulation of neuron differentiation; eye photoreceptor cell development; organ morphogenesis; response to ethanol; cellular response to insulin stimulus; retina development in camera-type eye; rhombomere morphogenesis; regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment; forebrain anterior/posterior pattern formation; positive regulation of transcription from RNA polymerase II promoter; lens development in camera-type eye; transcription from RNA polymerase II promoter; axon guidance; regulation of asymmetric cell division; neuron migration; forebrain dorsal/ventral pattern formation; dorsal/ventral axis specification; negative regulation of transcription from RNA polymerase II promoter; cerebral cortex regionalization; negative regulation of neurogenesis; astrocyte differentiation; visual perception; establishment of mitotic spindle orientation; negative regulation of protein amino acid phosphorylation; salivary gland morphogenesis; response to wounding; lacrimal gland development; regulation of timing of cell differentiation; negative regulation of epithelial cell proliferation; blood vessel development; smoothened signaling pathway; olfactory bulb development; eye development; protein localization in organelle; commitment of a neuronal cell to a specific type of neuron in the forebrain; pituitary gland development; regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification; regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification; embryonic camera-type eye morphogenesis

Disease: Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome; Peters Anomaly; Coloboma Of Optic Nerve; Keratitis, Hereditary; Aniridia, Cerebellar Ataxia, And Mental Retardation; Aniridia; Foveal Hypoplasia 1; Optic Nerve Hypoplasia, Bilateral
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 Research Articles on PAX6    1. findings suggest a central role of the WNT7A-PAX6 axis in corneal epithelial cell fate determination, and point to a new strategy for treating corneal surface diseases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PAX6 elisa kitPathways associated with PAX6 elisa kit
 Reference Product  PubMed Publications
 SOX2 elisa kit  >177 publications with PAX6 and SOX2
 SIX3 elisa kit  >79 publications with PAX6 and SIX3
 MITF elisa kit  >35 publications with PAX6 and MITF
 NEUROG2 elisa kit  >21 publications with PAX6 and NEUROG2
 SOX3 elisa kit  >20 publications with PAX6 and SOX3
 POU4F2 elisa kit  >6 publications with PAX6 and POU4F2
 GCG elisa kit  >4 publications with PAX6 and GCG
 MTOR elisa kit  >1 publications with PAX6 and MTOR
 HIPK2 elisa kit  >1 publications with PAX6 and HIPK2
 Products by Pathway  Pathway Diagram
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 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
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 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
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 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Regulation Of Beta-cell Development Pathway antibodies  Regulation Of Beta-cell Development Pathway Diagram
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Diseases associated with PAX6 elisa kitOrgans/Tissues associated with PAX6 elisa kit
 Disease Name  Pubmed Publications
 Aniridia Antibodies  >280 publications with PAX6 and Aniridia
 Nervous System Diseases Antibodies  >167 publications with PAX6 and Nervous System Diseases
 Brain Diseases Antibodies  >67 publications with PAX6 and Brain Diseases
 Disease Models, Animal Antibodies  >63 publications with PAX6 and Disease Models, Animal
 Nervous System Malformations Antibodies  >42 publications with PAX6 and Nervous System Malformations
 Intellectual Disability Antibodies  >40 publications with PAX6 and Intellectual Disability
 Peters anomaly Antibodies  >38 publications with PAX6 and Peters anomaly
 Coloboma Antibodies  >34 publications with PAX6 and Coloboma
 Craniofacial Abnormalities Antibodies  >29 publications with PAX6 and Craniofacial Abnormalities
 Diabetes Mellitus, Experimental Antibodies  >13 publications with PAX6 and Diabetes Mellitus, Experimental
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >18 publications with PAX6 and Skin
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