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PRPH2 elisa kit :: Human peripherin 2 (retinal degeneration, slow) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9316624 PRPH2 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

peripherin 2 (retinal degeneration, slow) (PRPH2), ELISA Kit

 Also Known As   

Human Peripherin-2, PRPH2 ELISA Kit

 Product Synonym Names    Human Peripherin-2 (PRPH2) ELISA kit; AOFMD; AVMD; CACD2; PRPH; RDS; RP7; TSPAN22; rd2; peripherin 2; peripherin 2; homolog of mouse; peripherin; photoreceptor type; retinal peripherin; tetraspanin-22; peripherin 2 (retinal degeneration; slow)
 Product Gene Name   

PRPH2 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    613105
 3D Structure    ModBase 3D Structure for P23942
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of PRPH2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PRPH2 purchase    MBS9316624 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the peripherin 2 (retinal degeneration, slow) (PRPH2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PRPH2. The ELISA analytical biochemical technique of the MBS9316624 kit is based on PRPH2 antibody-PRPH2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PRPH2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PRPH2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PRPH2. It may not necessarily be applicable to this product.
 NCBI GI #    118572596
 NCBI GeneID    5961
 NCBI Accession #    NP_000313.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000322.4 [Other Products]
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 UniProt Primary Accession #    P23942 [Other Products]
 UniProt Secondary Accession #    Q5TFH5; Q6DK65 [Other Products]
 UniProt Related Accession #    P23942 [Other Products]
 Molecular Weight    39,186 Da
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 NCBI Official Full Name    peripherin-2
 NCBI Official Synonym Full Names    peripherin 2 (retinal degeneration, slow)
 NCBI Official Symbol    PRPH2 [Similar Products]
 NCBI Official Synonym Symbols   
DS; RDS; RP7; rd2; AVMD; PRPH; AOFMD; CACD2; TSPAN22
[Similar Products]
 NCBI Protein Information    peripherin-2; tspan-22; tetraspanin-22; retinal peripherin; peripherin 2, homolog of mouse; peripherin, photoreceptor type; retinal degeneration slow protein
 UniProt Protein Name    Peripherin-2
 UniProt Synonym Protein Names   
Retinal degeneration slow protein; Tetraspanin-22; Tspan-22
 Protein Family    Peripherin
 UniProt Gene Name    PRPH2 [Similar Products]
 UniProt Synonym Gene Names    PRPH; RDS; TSPAN22; Tspan-22 [Similar Products]
 UniProt Entry Name    PRPH2_HUMAN
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 NCBI Summary for PRPH2    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRPH2    PRPH2: May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis. Defects in PRPH2 are the cause of retinitis pigmentosa type 7 (RP7). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in PRPH2 are a cause of retinitis punctata albescens (RPA). Defects in PRPH2 are a cause of adult-onset vitelliform macular dystrophy (AVMD). AVMD is a rare autosomal dominant disorder with incomplete penetrance and highly variable expression. Patients usually become symptomatic in the fourth or fifth decade of life with a protracted disease of decreased visual acuity. Defects in PRPH2 are a cause of patterned dystrophy of retinal pigment epithelium (PDREP). Patterned dystrophies of the retinal pigment epithelium (RPE) refer to a heterogeneous group of macular disorders. Three main types of PDREP have been described: reticular (fishnet-like) dystrophy, macroreticular (spider-shaped) dystrophy and butterfly-shaped pigment dystrophy. Defects in PRPH2 are a cause of choroidal dystrophy central areolar type 2 (CACD2). It is a disorder which affects the posterior pole of the eye, and early lesions consist of a non-specific area of granular hyperpigmentation at the fovea. The characteristic sign of the disorder, a zone of atrophy that develops in the macula of the eye and involves the retinal pigment epithelium and the choriocapillaris, occurs several decades after onset. Defects in PRPH2 are found in different retinal diseases including cone-rod dystrophy, retinitis pigmentosa, macular degeneration. The mutations underlying autosomal dominant retinitis pigmentosa and severe macular degeneration are largely missense or small in-frame deletions in a large intradiscal loop between the third and fourth transmembrane domains. In contrast, those associated with the milder pattern phenotypes or with digenic RP are scattered more evenly through the gene and are often nonsense mutations. This observation correlates with the hypothesis that the large loop is an important site of interaction between PRPH2 molecules and other protein components in the disk. Belongs to the PRPH2/ROM1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: integral to membrane

Biological Process: visual perception; retina development in camera-type eye; cell adhesion; response to low light intensity

Disease: Fundus Albipunctatus; Macular Dystrophy, Patterned, 1; Macular Dystrophy, Vitelliform, 3; Retinitis Pigmentosa 7; Choroidal Dystrophy, Central Areolar 2
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 Research Articles on PRPH2    1. Novel mutation c.389T > C (p.Leu130Pro) in PRPH2 was found in patients with retinitis pigmentosa and hearing loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRPH2 elisa kitPathways associated with PRPH2 elisa kit
 Reference Product  PubMed Publications
 PRPH elisa kit  >15 publications with PRPH2 and PRPH
 RHO elisa kit  >13 publications with PRPH2 and RHO
 ROM1 elisa kit  >6 publications with PRPH2 and ROM1
 BEST1 elisa kit  >6 publications with PRPH2 and BEST1
 TIMP3 elisa kit  >2 publications with PRPH2 and TIMP3
 CNGB1 elisa kit  >1 publications with PRPH2 and CNGB1
 MREG elisa kit  >1 publications with PRPH2 and MREG
 Products by Pathway  Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Diseases associated with PRPH2 elisa kitOrgans/Tissues associated with PRPH2 elisa kit
 Disease Name  Pubmed Publications
 Vitelliform Macular Dystrophy Antibodies  >7 publications with PRPH2 and Vitelliform Macular Dystrophy
 Retinitis Pigmentosa 7 Antibodies  >5 publications with PRPH2 and Retinitis Pigmentosa 7
 Inflammation Antibodies  >1 publications with PRPH2 and Inflammation
 Choroidal Dystrophy, Central Areolar 2 Antibodies  >1 publications with PRPH2 and Choroidal Dystrophy, Central Areolar 2
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >24 publications with PRPH2 and Eye
 Muscle Antibodies  >2 publications with PRPH2 and Muscle
 Brain Antibodies  >1 publications with PRPH2 and Brain
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