NP_001254480.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,134 Da
NCBI Official Full Name
phosphatidylethanolamine N-methyltransferase isoform 4
NCBI Official Synonym Full Names
phosphatidylethanolamine N-methyltransferase
NCBI Protein Information
phosphatidylethanolamine N-methyltransferase
UniProt Protein Name
Phosphatidylethanolamine N-methyltransferase
UniProt Synonym Protein Names
PEMT2
UniProt Synonym Gene Names
UniProt Entry Name
PEMT_HUMAN
NCBI Summary for PEMT
Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
UniProt Comments for PEMT
PEMT iso2: Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). Belongs to the PEMT/PEM2 methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Mitochondrial; Methyltransferase; Lipid Metabolism - glycerophospholipid; EC 2.1.1.71; Membrane protein, integral; Endoplasmic reticulum; EC 2.1.1.17
Chromosomal Location of Human Ortholog: 17p11.2
Cellular Component: endoplasmic reticulum membrane; mitochondrial membrane; integral to membrane
Molecular Function: phosphatidyl-N-methylethanolamine N-methyltransferase activity; phosphatidylethanolamine N-methyltransferase activity
Biological Process: methylation; cell proliferation; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process; lipid metabolic process
Research Articles on PEMT
Precautions
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Disclaimer
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Pathways associated with PEMT elisa kit
Diseases associated with PEMT elisa kit
Organs/Tissues associated with PEMT elisa kit
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