XP_008766504.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,185 Da
NCBI Official Full Name
microtubule-associated protein tau isoform X14
NCBI Official Synonym Full Names
microtubule-associated protein tau
NCBI Protein Information
microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; Tau microtubule-associated protein
UniProt Protein Name
Microtubule-associated protein tau
UniProt Synonym Protein Names
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
UniProt Synonym Gene Names
UniProt Entry Name
TAU_RAT
NCBI Summary for pMAPT/pTAU
a microtubule-associated protein; expression is found specifically in neurons [RGD, Feb 2006]
UniProt Comments for pMAPT/pTAU
Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.
Protein type: Cytoskeletal
Cellular Component: microtubule; neuron projection; cell; postsynaptic density; cytosol; microtubule cytoskeleton; growth cone; axon; cytoplasm; tubulin complex; plasma membrane; axoneme; intracellular; nucleus
Molecular Function: protein domain specific binding; protein binding; enzyme binding; protein phosphatase 2A binding; microtubule binding; protein complex binding; apolipoprotein binding; SH3 domain binding; protein kinase binding
Biological Process: axon extension; apoptosis; positive regulation of axon extension; positive regulation of microtubule polymerization; axon cargo transport; neuron migration; female pregnancy; microtubule cytoskeleton organization and biogenesis; adult walking behavior; mitochondrion transport along microtubule; microtubule-based process; response to organic substance; neuron differentiation; axonogenesis; negative regulation of intracellular transport; regulation of autophagy; brain development; induction of apoptosis by oxidative stress; response to nutrient
Research Articles on pMAPT/pTAU
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with pMAPT/pTAU elisa kit
Organs/Tissues associated with pMAPT/pTAU elisa kit
|