NP_000921.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,917 Da
NCBI Official Full Name
tissue-type plasminogen activator isoform 1 preproprotein
NCBI Official Synonym Full Names
plasminogen activator, tissue
NCBI Official Synonym Symbols
NCBI Protein Information
tissue-type plasminogen activator; alteplase; reteplase; t-plasminogen activator; plasminogen activator, tissue type; tissue plasminogen activator (t-PA)
UniProt Protein Name
Tissue-type plasminogen activator
UniProt Synonym Protein Names
INN: Alteplase; INN: ReteplaseCleaved into the following 2 chains:Tissue-type plasminogen activator chain A; Tissue-type plasminogen activator chain B
UniProt Synonym Gene Names
UniProt Entry Name
TPA_HUMAN
NCBI Summary for PLAT
This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for PLAT
Function: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
Catalytic activity: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Enzyme regulation: Inhibited by SERPINA5.1 PublicationManual assertion based on experiment in:Ref.24
Research Articles on PLAT
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Products associated with PLAT elisa kit
Pathways associated with PLAT elisa kit
Diseases associated with PLAT elisa kit
Organs/Tissues associated with PLAT elisa kit
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