NP_004796.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,311 Da
NCBI Official Full Name
DNA-directed RNA polymerase II subunit RPB4
NCBI Official Synonym Full Names
polymerase (RNA) II (DNA directed) polypeptide D
NCBI Protein Information
DNA-directed RNA polymerase II subunit RPB4; RNA polymerase II subunit B4; RNA polymerase II 16 kDa subunit; RNA polymerase II subunit hsRBP4; DNA-directed RNA polymerase II subunit D; DNA-directed RNA polymerase II 16 kDa polypeptide
UniProt Protein Name
DNA-directed RNA polymerase II subunit RPB4
UniProt Synonym Protein Names
DNA-directed RNA polymerase II subunit D; RNA polymerase II 16 kDa subunit; RPB16
UniProt Synonym Gene Names
UniProt Entry Name
RPB4_HUMAN
NCBI Summary for POLR2D
This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for POLR2D
POLR2D: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA. Belongs to the eukaryotic RPB4 RNA polymerase subunit family.
Protein type: Transcription initiation complex; EC 2.7.7.6; Nucleotide Metabolism - purine; Transferase; RNA processing; Nucleotide Metabolism - pyrimidine
Chromosomal Location of Human Ortholog: 2q21
Cellular Component: nucleoplasm; DNA-directed RNA polymerase II, core complex; nucleus
Molecular Function: single-stranded RNA binding; translation initiation factor binding; DNA-directed RNA polymerase activity; nucleotide binding; single-stranded DNA binding
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; viral reproduction; positive regulation of viral transcription; somatic stem cell maintenance; RNA splicing; DNA repair; nuclear mRNA splicing, via spliceosome; positive regulation of translational initiation; mRNA export from nucleus during heat stress; mRNA capping; nucleotide-excision repair; transcription-coupled nucleotide-excision repair; RNA elongation from RNA polymerase II promoter; gene expression; mRNA catabolic process, deadenylation-dependent decay
Research Articles on POLR2D
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with POLR2D elisa kit
Pathways associated with POLR2D elisa kit
Diseases associated with POLR2D elisa kit
Organs/Tissues associated with POLR2D elisa kit
|