NP_002784.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,489 Da
NCBI Official Full Name
proteasome subunit beta type-1
NCBI Official Synonym Full Names
proteasome (prosome, macropain) subunit, beta type, 1
NCBI Protein Information
proteasome subunit beta type-1; macropain subunit C5; proteasome gamma chain; proteasome subunit HC5; proteasome component C5; proteasome beta 1 subunit; multicatalytic endopeptidase complex subunit C5
UniProt Protein Name
Proteasome subunit beta type-1
UniProt Synonym Protein Names
Macropain subunit C5; Multicatalytic endopeptidase complex subunit C5; Proteasome component C5; Proteasome gamma chain
UniProt Synonym Gene Names
UniProt Entry Name
PSB1_HUMAN
NCBI Summary for PSMB1
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008]
UniProt Comments for PSMB1
PSMB1: a proteasomal protein of the T1B peptidase family. The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway.
Protein type: Protease; Cell cycle regulation; Proteasome complex; EC 3.4.25.1
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: nucleoplasm; proteasome complex; proteasome core complex; nucleus; cytosol
Molecular Function: threonine endopeptidase activity; protein binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
Research Articles on PSMB1
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Products associated with PSMB1 elisa kit
Pathways associated with PSMB1 elisa kit
Diseases associated with PSMB1 elisa kit
Organs/Tissues associated with PSMB1 elisa kit
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