NP_005392.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
135,261 Da
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 14
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 14
NCBI Official Synonym Symbols
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 14; protein-tyrosine phosphatase pez; cytoskeletal-associated protein tyrosine phosphatase
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 14
UniProt Synonym Protein Names
Protein-tyrosine phosphatase pez
UniProt Synonym Gene Names
UniProt Entry Name
PTN14_HUMAN
NCBI Summary for PTPN14
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]
UniProt Comments for PTPN14
PTPN14: a non-receptor phospho-tyrosine protein phosphatase. Reported to be mutated in a small percentage of human cancers including colorectal cancers and a smaller fraction of lung, breast, and gastric cancers. May play a role in liver metastases and tumour invasion in pancreatic cancer. Contains 1 FERM domain.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.2
Cellular Component: nucleoplasm; cytoskeleton; cytoplasm; nucleus
Molecular Function: protein binding; transcription cofactor activity; protein tyrosine phosphatase activity; receptor tyrosine kinase binding
Biological Process: negative regulation of cell proliferation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; lymphangiogenesis; protein amino acid dephosphorylation; regulation of protein export from nucleus
Disease: Choanal Atresia And Lymphedema
Research Articles on PTPN14
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Products associated with PTPN14 elisa kit
Diseases associated with PTPN14 elisa kit
Organs/Tissues associated with PTPN14 elisa kit
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