NP_001138840.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
103,990 Da
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 3 isoform 2
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 3
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 3; protein-tyrosine phosphatase H1; cytoskeletal-associated protein tyrosine phosphatase
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 3
UniProt Synonym Protein Names
Protein-tyrosine phosphatase H1; PTP-H1
UniProt Synonym Gene Names
UniProt Entry Name
PTN3_HUMAN
NCBI Summary for PTPN3
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
UniProt Comments for PTPN3
PTPN3: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Protein type: EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q31
Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm
Molecular Function: protein binding; sodium channel regulator activity; phosphotyrosine binding; cytoskeletal protein binding; protein tyrosine phosphatase activity; ATPase binding
Biological Process: negative regulation of mitotic cell cycle; protein amino acid dephosphorylation; negative regulation of membrane protein ectodomain proteolysis
Research Articles on PTPN3
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Products associated with PTPN3 elisa kit
Pathways associated with PTPN3 elisa kit
Diseases associated with PTPN3 elisa kit
Organs/Tissues associated with PTPN3 elisa kit
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