NP_002555.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,273 Da
NCBI Official Full Name
P2Y purinoceptor 2
NCBI Official Synonym Full Names
purinergic receptor P2Y, G-protein coupled, 2
NCBI Official Synonym Symbols
P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R [Similar Products]
NCBI Protein Information
P2Y purinoceptor 2; ATP receptor; P2U receptor 1; purinoceptor P2Y2; P2U purinoceptor 1; P2U nucleotide receptor; purinergic receptor P2Y2
UniProt Protein Name
P2Y purinoceptor 2
UniProt Synonym Protein Names
ATP receptor; P2U purinoceptor 1; P2U1; P2U receptor 1; Purinergic receptor
UniProt Synonym Gene Names
UniProt Entry Name
P2RY2_HUMAN
NCBI Summary for P2RY2
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
UniProt Comments for P2RY2
P2Y2: a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc.; Membrane protein, integral; GPCR, family 1
Chromosomal Location of Human Ortholog: 11q13.5-q14.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: purinergic nucleotide receptor activity, G-protein coupled; receptor activity
Biological Process: regulation of vasodilation; cellular ion homeostasis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
Research Articles on P2RY2
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Products associated with P2RY2 elisa kit
Pathways associated with P2RY2 elisa kit
Diseases associated with P2RY2 elisa kit
Organs/Tissues associated with P2RY2 elisa kit
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