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PYCR1 elisa kit :: Human pyrroline-5-carboxylate reductase 1 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9332357 PYCR1 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

pyrroline-5-carboxylate reductase 1 (PYCR1), ELISA Kit

 Also Known As   

Human Pyrroline-5-carboxylate reductase 1, mitochondrial, PYCR1 ELISA Kit

 Product Synonym Names    Human Pyrroline-5-carboxylate reductase 1; mitochondrial (PYCR1) ELISA kit; ARCL2B; P5C; P5CR; PIG45; PP222; PRO3; PYCR; P5C reductase; proliferation-inducing protein 45; pyrroline-5-carboxylate reductase 1
 Product Gene Name   

PYCR1 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Manual Insert    Request Manual
 OMIM    614438
 3D Structure    ModBase 3D Structure for P32322
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay.
 Other Notes    Small volumes of PYCR1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for PYCR1 purchase    MBS9332357 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the pyrroline-5-carboxylate reductase 1 (PYCR1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing PYCR1. The ELISA analytical biochemical technique of the MBS9332357 kit is based on PYCR1 antibody-PYCR1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect PYCR1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, PYCR1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for PYCR1. It may not necessarily be applicable to this product.
 NCBI GI #    533112488
 NCBI GeneID    5831
 NCBI Accession #    NP_001269209.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001282280.1 [Other Products]
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 UniProt Primary Accession #    P32322 [Other Products]
 UniProt Secondary Accession #    Q6FHI4; Q96DI6; Q9HBQ4; A6NFM2; B4DMU0 [Other Products]
 UniProt Related Accession #    P32322 [Other Products]
 Molecular Weight    33,361 Da
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 NCBI Official Full Name    pyrroline-5-carboxylate reductase 1, mitochondrial isoform 1
 NCBI Official Synonym Full Names    pyrroline-5-carboxylate reductase 1
 NCBI Official Symbol    PYCR1 [Similar Products]
 NCBI Official Synonym Symbols   
P5C; P5CR; PRO3; PYCR; PIG45; PP222; ARCL2B; ARCL3B
[Similar Products]
 NCBI Protein Information    pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; proliferation-inducing protein 45
 UniProt Protein Name    Pyrroline-5-carboxylate reductase 1, mitochondrial
 Protein Family    Pyrroline-5-carboxylate reductase
 UniProt Gene Name    PYCR1 [Similar Products]
 UniProt Synonym Gene Names    P5C reductase 1; P5CR 1 [Similar Products]
 UniProt Entry Name    P5CR1_HUMAN
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 NCBI Summary for PYCR1    This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for PYCR1    PYCR1: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress. Defects in PYCR1 are the cause of cutis laxa autosomal recessive type 2B (ARCL2B). A multisystem disorder characterized by the appearance of premature aging, wrinkled and lax skin with reduced elasticity, joint laxity, craniofacial dysmorphic features, intrauterine growth retardation with some degree of postnatal growth deficiency, and developmental delay. Defects in PYCR1 are the cause of cutis laxa, autosomal recessive, type 3B (ARCL3B). ARCL3B is a disorder characterized by an aged appearance with distinctive facial features, sparse hair, ophthalmologic abnormalities, intrauterine growth retardation, and cutis laxa. Belongs to the pyrroline-5-carboxylate reductase family.

Protein type: EC 1.5.1.2; Oxidoreductase; Amino Acid Metabolism - arginine and proline; Mitochondrial

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: identical protein binding; protein binding; pyrroline-5-carboxylate reductase activity

Biological Process: regulation of mitochondrial membrane potential; proline biosynthetic process; amino acid biosynthetic process

Disease: Cutis Laxa, Autosomal Recessive, Type Iib; Cutis Laxa, Autosomal Recessive, Type Iiib
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 Research Articles on PYCR1    1. our current study presents the second largest group of patients with PYCR1-related ARCL and expands the clinical and genetic spectrum.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with PYCR1 elisa kitDiseases associated with PYCR1 elisa kit
 Products by Pathway  Pathway Diagram
 Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies  Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Proline Biosynthesis, Glutamate => Proline Pathway antibodies  Proline Biosynthesis, Glutamate => Proline Pathway Diagram
 Proline Biosynthesis, Glutamate => Proline Pathway antibodies  Proline Biosynthesis, Glutamate => Proline Pathway Diagram
 Urea Cycle And Metabolism Of Amino Groups Pathway antibodies  Urea Cycle And Metabolism Of Amino Groups Pathway Diagram
 Arginine Degradation VI (arginase 2 Pathway) antibodies  Arginine Degradation VI (arginase 2 Pathway) Diagram
 Proline Biosynthesis I Pathway antibodies  Proline Biosynthesis I Pathway Diagram
 Disease Name  Pubmed Publications
 Cutis Laxa Antibodies  >9 publications with PYCR1 and Cutis Laxa
 Neoplasms Antibodies  >5 publications with PYCR1 and Neoplasms
 Congenital Abnormalities Antibodies  >5 publications with PYCR1 and Congenital Abnormalities
 Carcinoma Antibodies  >4 publications with PYCR1 and Carcinoma
 Adenocarcinoma Antibodies  >3 publications with PYCR1 and Adenocarcinoma
 Prostatic Diseases Antibodies  >2 publications with PYCR1 and Prostatic Diseases
 Prostatic Neoplasms Antibodies  >2 publications with PYCR1 and Prostatic Neoplasms
 CUTIS LAXA, AUTOSOMAL RECESSIVE, TYPE IIB Antibodies  >2 publications with PYCR1 and CUTIS LAXA, AUTOSOMAL RECESSIVE, TYPE IIB
 Precancerous Conditions Antibodies  >1 publications with PYCR1 and Precancerous Conditions
 Lung Neoplasms Antibodies  >1 publications with PYCR1 and Lung Neoplasms
Organs/Tissues associated with PYCR1 elisa kit
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with PYCR1 and Skin
 Bone Antibodies  >3 publications with PYCR1 and Bone
 Prostate Antibodies  >2 publications with PYCR1 and Prostate
 Connective Tissue Antibodies  >1 publications with PYCR1 and Connective Tissue
 Blood Antibodies  >1 publications with PYCR1 and Blood
 Lung Antibodies  >1 publications with PYCR1 and Lung
 Brain Antibodies  >1 publications with PYCR1 and Brain
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