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RNASEH2C elisa kit :: Human ribonuclease H2, subunit C ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9324458 RNASEH2C elisa kit
Unit / Price
48-Strip-Wells  /  $470 +1 FREE 8GB USB
96-Strip-Wells  /  $680 +1 FREE 8GB USB
5x96-Strip-Wells  /  $3,100 +3 FREE 8GB USB
10x96-Strip-Wells  /  $6,095 +7 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ribonuclease H2, subunit C (RNASEH2C), ELISA Kit

 Also Known As   

Human Ribonuclease H2 subunit C, RNASEH2C ELISA Kit

 Product Synonym Names    Human Ribonuclease H2 subunit C (RNASEH2C) ELISA kit; AGS3; AYP1; FLJ20974; MGC22934; RNase H1 small subunit; ribonuclease H2; subunit C
 Product Gene Name   

RNASEH2C elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    610330
 3D Structure    ModBase 3D Structure for Q8TDP1
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of RNASEH2C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for RNASEH2C purchase    MBS9324458 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ribonuclease H2, subunit C (RNASEH2C) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing RNASEH2C. The ELISA analytical biochemical technique of the MBS9324458 kit is based on RNASEH2C antibody-RNASEH2C antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect RNASEH2C antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, RNASEH2C. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for RNASEH2C. It may not necessarily be applicable to this product.
 NCBI GI #    38176285
 NCBI GeneID    84153
 NCBI Accession #    NP_115569.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032193.3 [Other Products]
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 UniProt Primary Accession #    Q8TDP1 [Other Products]
 UniProt Secondary Accession #    Q9H7F5 [Other Products]
 UniProt Related Accession #    Q8TDP1 [Other Products]
 Molecular Weight    17,840 Da
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 NCBI Official Full Name    ribonuclease H2 subunit C
 NCBI Official Synonym Full Names    ribonuclease H2, subunit C
 NCBI Official Symbol    RNASEH2C [Similar Products]
 NCBI Official Synonym Symbols   
AGS3; AYP1
[Similar Products]
 NCBI Protein Information    ribonuclease H2 subunit C; RNase H2 subunit C; RNase H1 small subunit; ribonuclease HI subunit C; aicardi-Goutieres syndrome 3 protein
 UniProt Protein Name    Ribonuclease H2 subunit C
 UniProt Synonym Protein Names   
Aicardi-Goutieres syndrome 3 protein; AGS3; RNase H1 small subunit; Ribonuclease HI subunit C
 Protein Family    Ribonuclease
 UniProt Gene Name    RNASEH2C [Similar Products]
 UniProt Synonym Gene Names    AYP1; RNase H2 subunit C; AGS3 [Similar Products]
 UniProt Entry Name    RNH2C_HUMAN
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 NCBI Summary for RNASEH2C    This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for RNASEH2C    RNASEH2C: Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. Defects in RNASEH2C are the cause of Aicardi-Goutieres syndrome type 3 (AGS3). A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. Belongs to the RNase H2 subunit C family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA replication

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: nucleus

Biological Process: RNA catabolic process

Disease: Aicardi-goutieres Syndrome 3
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 Research Articles on RNASEH2C    1. Examination of the effect of several Aicardi-Goutieres Syndrome-related mutations in the C subunit of RNase H2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with RNASEH2C elisa kitDiseases associated with RNASEH2C elisa kit
 Products by Pathway  Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 Disease Name  Pubmed Publications
 Aicardi-Goutieres syndrome Antibodies  >4 publications with RNASEH2C and Aicardi-Goutieres syndrome
 Neurologic Manifestations Antibodies  >1 publications with RNASEH2C and Neurologic Manifestations
Organs/Tissues associated with RNASEH2C elisa kit
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with RNASEH2C and Skin
 Liver Antibodies  >1 publications with RNASEH2C and Liver
 Brain Antibodies  >1 publications with RNASEH2C and Brain
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