NP_001017368.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
E3 ubiquitin-protein ligase rififylin
NCBI Official Synonym Full Names
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
NCBI Official Synonym Symbols
CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN [Similar Products]
NCBI Protein Information
E3 ubiquitin-protein ligase rififylin; RING finger protein 189; caspase regulator CARP2; FYVE-RING finger protein SAKURA; ring finger and FYVE-like domain containing 1; caspases-8 and -10-associated RING finger protein 2; RING finger and FYVE-like domain-containing protein 1
UniProt Protein Name
E3 ubiquitin-protein ligase rififylin
UniProt Synonym Protein Names
Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; CARP-2; FYVE-RING finger protein Sakura; Fring; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like
UniProt Synonym Gene Names
UniProt Entry Name
RFFL_HUMAN
UniProt Comments for RFFL
RFFL: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Vesicle; Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: Golgi membrane; membrane; recycling endosome membrane; lysosome; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; endosome membrane; cytosol
Molecular Function: protein binding; protease binding; zinc ion binding; p53 binding; ubiquitin protein ligase binding; protein kinase binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; intracellular protein transport; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway
Research Articles on RFFL
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Pathways associated with RFFL elisa kit
Diseases associated with RFFL elisa kit
Organs/Tissues associated with RFFL elisa kit
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