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SEL1L elisa kit :: Human sel-1 suppressor of lin-12-like (C. elegans) ELISA Kit

Scan QR to view Datasheet Catalog #    MBS926794
Typical Testing Data/Standard Curve (for reference only)
Unit / Price
48-Strip-Wells  /  $495 +1 FREE 8GB USB
96-Strip-Wells  /  $710 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,550 +3 FREE 8GB USB
10x96-Strip-Wells  /  $4,815 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

sel-1 suppressor of lin-12-like (C. elegans) (SEL1L), ELISA Kit

 Also Known As   

Human Protein sel-1 homolog 1, SEL1L ELISA Kit

 Product Synonym Names    Human Protein sel-1 homolog 1 (SEL1L) ELISA kit; IBD2; PRO1063; SEL1-LIKE; SEL1L1; Suppressor of lin 12 (sel-1); C. elegans; homolog of; sel-1 (suppressor of lin-12; C.elegans) -like; sel-1 suppressor of lin-12-like; sel-1 suppressor of lin-12-like 1; sel-1 suppressor of lin-12-like (C. elegans)
 Product Gene Name   

SEL1L elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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  Manual Insert    Download PDF Manual View PDF Manual
 MBS926794 Testing Data    Testing Data PDF
 OMIM    602329
 3D Structure    ModBase 3D Structure for Q9UBV2
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 Species Reactivity    Human
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 Specificity    This assay has high sensitivity and excellent specificity for detection of human SEL1L. No significant cross-reactivity or interference between human SEL1L and analogues was observed.
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 Samples    Serum, plasma, tissue homogenates
 Assay Type    Sandwich
 Detection Range    18.75 pg/ml -1200 pg/ml.
 Sensitivity    The minimum detectable dose of human SEL1L is typically less than 4.7 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
 Intra-assay Precision    Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess.
 Inter-assay Precision    Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
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 Preparation and Storage    Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SEL1L elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SEL1L purchase    MBS926794 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the sel-1 suppressor of lin-12-like (C. elegans) (SEL1L) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 18.75 pg/ml -1200 pg/ml in biological research samples containing SEL1L, with an estimated sensitivity of The minimum detectable dose of human SEL1L is typically less than 4.7 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. The ELISA analytical biochemical technique of the MBS926794 kit is based on SEL1L antibody-SEL1L antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SEL1L antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SEL1L. Appropriate sample types may include undiluted human body fluids and/or tissue homogenates, secretions such as Serum, plasma, tissue homogenates. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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Product Description specifically for SEL1L elisa kit

   Principle of the assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for SEL1L has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any SEL1L present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for SEL1L is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of SEL1L bound in the initial step. The color development is stopped and the intensity of the color is measured.
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 Typical Testing Data/Standard Curve (for reference only) of SEL1L elisa kit    SEL1L elisa kit Typical Testing Data/Standard Curve (for reference only) image
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Sample Manual Insert of MBS926794
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NCBI/Uniprot data below describe general gene information for SEL1L. It may not necessarily be applicable to this product.
 NCBI GI #    350529338
 NCBI GeneID    6400
 NCBI Accession #    NP_001231913.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001244984.1 [Other Products]
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 UniProt Primary Accession #    Q9UBV2 [Other Products]
 UniProt Secondary Accession #    Q6UWT6; Q9P1T9; Q9UHK7 [Other Products]
 UniProt Related Accession #    Q9UBV2 [Other Products]
 Molecular Weight    88,755 Da
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 NCBI Official Full Name    protein sel-1 homolog 1 isoform 2
 NCBI Official Synonym Full Names    sel-1 suppressor of lin-12-like (C. elegans)
 NCBI Official Symbol    SEL1L [Similar Products]
 NCBI Official Synonym Symbols   
SEL1L1; PRO1063; SEL1-LIKE
[Similar Products]
 NCBI Protein Information    protein sel-1 homolog 1; sel-1 suppressor of lin-12-like 1; suppressor of lin-12-like protein 1; Suppressor of lin 12 (sel-1), C. elegans, homolog of
 UniProt Protein Name    Protein sel-1 homolog 1
 UniProt Synonym Protein Names   
Suppressor of lin-12-like protein 1; Sel-1L
 Protein Family    Protein
 UniProt Gene Name    SEL1L [Similar Products]
 UniProt Synonym Gene Names    TSA305; UNQ128/PRO1063; Sel-1L [Similar Products]
 UniProt Entry Name    SE1L1_HUMAN
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 NCBI Summary for SEL1L    The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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 UniProt Comments for SEL1L    SEL1L: May play a role in Notch signaling. May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Belongs to the sel-1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q31

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: protein binding

Biological Process: Notch signaling pathway; ER-associated protein catabolic process
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 Research Articles on SEL1L    1. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin signalling to create a favourable micro-environment for ss-cell development and function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SEL1L elisa kitDiseases associated with SEL1L elisa kit
 Products by Pathway  Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 Pre-NOTCH Expression And Processing Pathway antibodies  Pre-NOTCH Expression And Processing Pathway Diagram
 Pre-NOTCH Processing In Golgi Pathway antibodies  Pre-NOTCH Processing In Golgi Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By NOTCH Pathway antibodies  Signaling By NOTCH Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with SEL1L and Neoplasms
 Carcinoma Antibodies  >14 publications with SEL1L and Carcinoma
 Adenocarcinoma Antibodies  >7 publications with SEL1L and Adenocarcinoma
 Breast Neoplasms Antibodies  >6 publications with SEL1L and Breast Neoplasms
 Nervous System Diseases Antibodies  >6 publications with SEL1L and Nervous System Diseases
 Gastrointestinal Diseases Antibodies  >6 publications with SEL1L and Gastrointestinal Diseases
 Cell Transformation, Neoplastic Antibodies  >4 publications with SEL1L and Cell Transformation, Neoplastic
 Lung Neoplasms Antibodies  >4 publications with SEL1L and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >3 publications with SEL1L and Carcinoma, Squamous Cell
 Esophageal Neoplasms Antibodies  >3 publications with SEL1L and Esophageal Neoplasms
Organs/Tissues associated with SEL1L elisa kit
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >14 publications with SEL1L and Pancreas
 Blood Antibodies  >4 publications with SEL1L and Blood
 Embryonic Tissue Antibodies  >4 publications with SEL1L and Embryonic Tissue
 Lung Antibodies  >4 publications with SEL1L and Lung
 Esophagus Antibodies  >2 publications with SEL1L and Esophagus
 Liver Antibodies  >2 publications with SEL1L and Liver
 Stomach Antibodies  >2 publications with SEL1L and Stomach
 Lymph Node Antibodies  >1 publications with SEL1L and Lymph Node
 Prostate Antibodies  >1 publications with SEL1L and Prostate
 Kidney Antibodies  >1 publications with SEL1L and Kidney
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