NP_001159828.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,993 Da
NCBI Official Full Name
serine hydroxymethyltransferase, mitochondrial isoform 2
NCBI Official Synonym Full Names
serine hydroxymethyltransferase 2 (mitochondrial)
NCBI Protein Information
serine hydroxymethyltransferase, mitochondrial; GLY A+; serine aldolase; serine methylase; threonine aldolase; serine hydroxymethylase; glycine hydroxymethyltransferase; epididymis secretory sperm binding protein Li 51e; glycine auxotroph A, human complement for hamster
UniProt Protein Name
Serine hydroxymethyltransferase, mitochondrial
UniProt Synonym Protein Names
Glycine hydroxymethyltransferase; Serine methylase
UniProt Synonym Gene Names
UniProt Entry Name
GLYM_HUMAN
NCBI Summary for SHMT2
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
UniProt Comments for SHMT2
SHMT2: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Other Amino Acids Metabolism - cyanoamino acid; Energy Metabolism - methane; Mitochondrial; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Amino Acid Metabolism - glycine, serine and threonine; Methyltransferase
Chromosomal Location of Human Ortholog: 12q12-q14
Cellular Component: microtubule cytoskeleton; mitochondrion; mitochondrial matrix; mitochondrial inner membrane; mitochondrial intermembrane space
Molecular Function: L-allo-threonine aldolase activity; identical protein binding; amino acid binding; glycine hydroxymethyltransferase activity; chromatin binding; pyridoxal phosphate binding
Biological Process: L-serine biosynthetic process; positive regulation of cell proliferation; one-carbon compound metabolic process; glycine biosynthetic process from serine; protein homotetramerization
Research Articles on SHMT2
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Pathways associated with SHMT2 elisa kit
Diseases associated with SHMT2 elisa kit
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