P51866.1
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
82,586 Da
NCBI Official Full Name
Platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet/endothelial cell adhesion molecule<
NCBI Protein Information
platelet endothelial cell adhesion molecule; PECAM-1; CD31 antigen; platelet/endothelial cell adhesion molecule (CD31 antigen)
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
CD_antigen: CD31
UniProt Synonym Gene Names
UniProt Entry Name
PECA1_BOVIN
UniProt Comments for sPECAM1/sCD31
Function: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-689 plays a critical role in transendothelial migration (TEM) and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of CD31 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of CD31 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation. Induces susceptibility to atherosclerosis
Research Articles on sPECAM1/sCD31
Precautions
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Products associated with sPECAM1/sCD31 elisa kit
Pathways associated with sPECAM1/sCD31 elisa kit
Organs/Tissues associated with sPECAM1/sCD31 elisa kit
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