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SLC12A3 elisa kit :: Human solute carrier family 12 (sodium/chloride transporters) , member 3 ELISA Kit

Scan QR to view Datasheet Catalog #    MBS9335852 SLC12A3 elisa kit
Unit / Price
48-Strip-Wells  /  $435 +1 FREE 8GB USB
96-Strip-Wells  /  $600 +1 FREE 8GB USB
5x96-Strip-Wells  /  $2,650 +3 FREE 8GB USB
10x96-Strip-Wells  /  $5,205 +6 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

solute carrier family 12 (sodium/chloride transporters) , member 3 (SLC12A3), ELISA Kit

 Also Known As   

Human Solute carrier family 12 member 3, SLC12A3 ELISA Kit

 Product Synonym Names    Human Solute carrier family 12 member 3 (SLC12A3) ELISA kit; FLJ96318; NCCT; TSC; Na-Cl symporter; NaCl electroneutral thiazide-sensitive cotransporter; solute carrier family 12; member 3; thiazide-sensitive Na-Cl cotransporter; solute carrier family 12 (sodium/chloride transporters); member 3
 Product Gene Name   

SLC12A3 elisa kit

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Request for Current Manual Insert    Request Current Manual
 OMIM    600968
 3D Structure    ModBase 3D Structure for P55017
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 Species Reactivity    Human
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 Preparation and Storage    Store all reagents at 2-8 degree C
 Product Note    Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
 Other Notes    Small volumes of SLC12A3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
 Searchable Terms for SLC12A3 purchase    MBS9335852 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC12A3. The ELISA analytical biochemical technique of the MBS9335852 kit is based on SLC12A3 antibody-SLC12A3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC12A3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC12A3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).
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NCBI/Uniprot data below describe general gene information for SLC12A3. It may not necessarily be applicable to this product.
 NCBI GI #    186910315
 NCBI GeneID    6559
 NCBI Accession #    NP_000330.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000339.2 [Other Products]
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 UniProt Primary Accession #    P55017 [Other Products]
 UniProt Secondary Accession #    A8MSJ2; C9JNN9 [Other Products]
 UniProt Related Accession #    P55017 [Other Products]
 Molecular Weight    113,139 Da
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 NCBI Official Full Name    solute carrier family 12 member 3 isoform 1
 NCBI Official Synonym Full Names    solute carrier family 12 (sodium/chloride transporter), member 3
 NCBI Official Symbol    SLC12A3 [Similar Products]
 NCBI Official Synonym Symbols   
NCC; TSC; NCCT
[Similar Products]
 NCBI Protein Information    solute carrier family 12 member 3; Na-Cl symporter; Na-Cl cotransporter; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; NaCl electroneutral thiazide-sensitive cotransporter
 UniProt Protein Name    Solute carrier family 12 member 3
 UniProt Synonym Protein Names   
Na-Cl cotransporter; NCC; Na-Cl symporter; Thiazide-sensitive sodium-chloride cotransporter
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC12A3 [Similar Products]
 UniProt Synonym Gene Names    NCC; TSC; NCC [Similar Products]
 UniProt Entry Name    S12A3_HUMAN
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 NCBI Summary for SLC12A3    This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SLC12A3    NCCT: Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane; cytosol

Molecular Function: protein binding; transporter activity; sodium:chloride symporter activity

Biological Process: transport; sodium ion transport; chloride transport; ion transport; transmembrane transport

Disease: Gitelman Syndrome
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 Research Articles on SLC12A3    1. a model where NCC is constitutively cycled to the plasma membrane, and upon stimulation, it can be phosphorylated to both increase NCC activity and decrease NCC endocytosis, together increasing NaCl transport in the DCT.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SLC12A3 elisa kitPathways associated with SLC12A3 elisa kit
 Reference Product  PubMed Publications
 WNK4 elisa kit  >17 publications with SLC12A3 and WNK4
 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with SLC12A3 elisa kitOrgans/Tissues associated with SLC12A3 elisa kit
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >124 publications with SLC12A3 and Kidney Diseases
 Gitelman Syndrome Antibodies  >80 publications with SLC12A3 and Gitelman Syndrome
 Hypokalemia Antibodies  >74 publications with SLC12A3 and Hypokalemia
 Hypertension Antibodies  >58 publications with SLC12A3 and Hypertension
 Hyperaldosteronism Antibodies  >39 publications with SLC12A3 and Hyperaldosteronism
 Hypertension, Renal Antibodies  >32 publications with SLC12A3 and Hypertension, Renal
 Hyperkalemia Antibodies  >12 publications with SLC12A3 and Hyperkalemia
 Hypotension Antibodies  >11 publications with SLC12A3 and Hypotension
 Hypercalciuria Antibodies  >11 publications with SLC12A3 and Hypercalciuria
 Magnesium Deficiency Antibodies  >10 publications with SLC12A3 and Magnesium Deficiency
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >130 publications with SLC12A3 and Kidney
 Mixed Antibodies  >2 publications with SLC12A3 and Mixed
 Placenta Antibodies  >1 publications with SLC12A3 and Placenta
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