NP_001258694.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
54,994 Da
NCBI Official Full Name
monocarboxylate transporter 6
NCBI Official Synonym Full Names
solute carrier family 16 (monocarboxylate transporter), member 5
NCBI Official Synonym Symbols
NCBI Protein Information
monocarboxylate transporter 6; monocarboxylate transporter 5; solute carrier family 16 (monocarboxylic acid transporters), member 5; solute carrier family 16, member 5 (monocarboxylic acid transporter 6)
UniProt Protein Name
Monocarboxylate transporter 6
UniProt Synonym Protein Names
Monocarboxylate transporter 5; MCT 5; Solute carrier family 16 member 5
UniProt Synonym Gene Names
UniProt Entry Name
MOT6_HUMAN
NCBI Summary for SLC16A5
This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
UniProt Comments for SLC16A5
SLC16A5: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component: membrane; integral to plasma membrane
Molecular Function: monocarboxylic acid transmembrane transporter activity; symporter activity; lactate transmembrane transporter activity; secondary active monocarboxylate transmembrane transporter activity
Biological Process: monocarboxylic acid transport
Research Articles on SLC16A5
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Organs/Tissues associated with SLC16A5 elisa kit
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